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Hierarchical Modularity in ERα Transcriptional Network Is Associated with Distinct Functions and Implicates Clinical Outcomes

Recent genome-wide profiling reveals highly complex regulation networks among ERα and its targets. We integrated estrogen (E2)-stimulated time-series ERα ChIP-seq and gene expression data to identify the ERα-centered transcription factor (TF) hubs and their target genes, and inferred the time-varian...

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Detalles Bibliográficos
Autores principales:	Tang, Binhua, Hsu, Hang-Kai, Hsu, Pei-Yin, Bonneville, Russell, Chen, Su-Shing, Huang, Tim H-M., Jin, Victor X.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500769/ https://www.ncbi.nlm.nih.gov/pubmed/23166858 http://dx.doi.org/10.1038/srep00875

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