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Immunohistochemical study of epiretinal membranes in patients with uveitis

BACKGROUND: The purpose of this study is to report two cases of idiopathic uveitis with secondary epiretinal membrane (ERM) formation in order to describe histologic and immunohistochemical features that may help distinguish uveitic from idiopathic ERMs. METHODS: The study utilized a clinical case s...

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Autores principales: Sheybani, Arsham, Harocopos, George J., Rao, P. Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500982/
https://www.ncbi.nlm.nih.gov/pubmed/22532244
http://dx.doi.org/10.1007/s12348-012-0074-x
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author Sheybani, Arsham
Harocopos, George J.
Rao, P. Kumar
author_facet Sheybani, Arsham
Harocopos, George J.
Rao, P. Kumar
author_sort Sheybani, Arsham
collection PubMed
description BACKGROUND: The purpose of this study is to report two cases of idiopathic uveitis with secondary epiretinal membrane (ERM) formation in order to describe histologic and immunohistochemical features that may help distinguish uveitic from idiopathic ERMs. METHODS: The study utilized a clinical case series and histopathological and immunohistochemical findings. RESULTS: There was no identifiable etiology of inflammation in either case. Histology and immunohistochemistry demonstrated a mixture of abundant inflammatory cells, including lymphocytes, histiocytes, plasma cells, and occasional eosinophils, among a stromal matrix composed of glial elements and condensed vitreous, but no retinal pigment epithelium (RPE) was present. The relative proportions of the various inflammatory cell types were assessed with immunohistochemistry, and among the lymphocyte population, T cells predominated over B cells. In one of the cases, there was an abundance of histiocytes, consistent with granulomatous uveitis, which was later confirmed on histology of the enucleated globe. CONCLUSIONS: Idiopathic ERM formation is thought to be secondary to glial cell migration that may require some involvement of RPE cells. The absence of RPE and abundance of inflammatory cells may be used to identify ERMs as secondary to uveitis.
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spelling pubmed-35009822012-12-06 Immunohistochemical study of epiretinal membranes in patients with uveitis Sheybani, Arsham Harocopos, George J. Rao, P. Kumar J Ophthalmic Inflamm Infect Discussion by Case BACKGROUND: The purpose of this study is to report two cases of idiopathic uveitis with secondary epiretinal membrane (ERM) formation in order to describe histologic and immunohistochemical features that may help distinguish uveitic from idiopathic ERMs. METHODS: The study utilized a clinical case series and histopathological and immunohistochemical findings. RESULTS: There was no identifiable etiology of inflammation in either case. Histology and immunohistochemistry demonstrated a mixture of abundant inflammatory cells, including lymphocytes, histiocytes, plasma cells, and occasional eosinophils, among a stromal matrix composed of glial elements and condensed vitreous, but no retinal pigment epithelium (RPE) was present. The relative proportions of the various inflammatory cell types were assessed with immunohistochemistry, and among the lymphocyte population, T cells predominated over B cells. In one of the cases, there was an abundance of histiocytes, consistent with granulomatous uveitis, which was later confirmed on histology of the enucleated globe. CONCLUSIONS: Idiopathic ERM formation is thought to be secondary to glial cell migration that may require some involvement of RPE cells. The absence of RPE and abundance of inflammatory cells may be used to identify ERMs as secondary to uveitis. Springer-Verlag 2012-04-25 /pmc/articles/PMC3500982/ /pubmed/22532244 http://dx.doi.org/10.1007/s12348-012-0074-x Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Discussion by Case
Sheybani, Arsham
Harocopos, George J.
Rao, P. Kumar
Immunohistochemical study of epiretinal membranes in patients with uveitis
title Immunohistochemical study of epiretinal membranes in patients with uveitis
title_full Immunohistochemical study of epiretinal membranes in patients with uveitis
title_fullStr Immunohistochemical study of epiretinal membranes in patients with uveitis
title_full_unstemmed Immunohistochemical study of epiretinal membranes in patients with uveitis
title_short Immunohistochemical study of epiretinal membranes in patients with uveitis
title_sort immunohistochemical study of epiretinal membranes in patients with uveitis
topic Discussion by Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500982/
https://www.ncbi.nlm.nih.gov/pubmed/22532244
http://dx.doi.org/10.1007/s12348-012-0074-x
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