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Correlation networks visualization
New, in silico ways of generating hypotheses based on large data sets have emerged in the past decade. These data sets have been used to investigate different aspects of plant biology, especially at the level of transcriptome, from tissue-specific expression patterns to patterns in as little as a fe...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500995/ https://www.ncbi.nlm.nih.gov/pubmed/23181065 http://dx.doi.org/10.3389/fpls.2012.00240 |
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author | Provart, Nicholas |
author_facet | Provart, Nicholas |
author_sort | Provart, Nicholas |
collection | PubMed |
description | New, in silico ways of generating hypotheses based on large data sets have emerged in the past decade. These data sets have been used to investigate different aspects of plant biology, especially at the level of transcriptome, from tissue-specific expression patterns to patterns in as little as a few cells. Such publicly available data are a boon to researchers for hypothesis generation by providing a guide for experimental work such as phenotyping or genetic analysis. More advanced computational methods can leverage these data via gene coexpression analysis, the results of which can be visualized and refined using network analysis. Other kinds of networks of, e.g., protein–protein interactions, can also be used to inform biology. These networks can be visualized and analyzed with additional information on gene expression levels, subcellular localization, etc., or with other emerging kinds information. Finally, cross-level correlation is an area that will become increasingly important. Visualizing these cross-level correlations will require new data visualization tools. |
format | Online Article Text |
id | pubmed-3500995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35009952012-11-23 Correlation networks visualization Provart, Nicholas Front Plant Sci Plant Science New, in silico ways of generating hypotheses based on large data sets have emerged in the past decade. These data sets have been used to investigate different aspects of plant biology, especially at the level of transcriptome, from tissue-specific expression patterns to patterns in as little as a few cells. Such publicly available data are a boon to researchers for hypothesis generation by providing a guide for experimental work such as phenotyping or genetic analysis. More advanced computational methods can leverage these data via gene coexpression analysis, the results of which can be visualized and refined using network analysis. Other kinds of networks of, e.g., protein–protein interactions, can also be used to inform biology. These networks can be visualized and analyzed with additional information on gene expression levels, subcellular localization, etc., or with other emerging kinds information. Finally, cross-level correlation is an area that will become increasingly important. Visualizing these cross-level correlations will require new data visualization tools. Frontiers Media S.A. 2012-10-29 /pmc/articles/PMC3500995/ /pubmed/23181065 http://dx.doi.org/10.3389/fpls.2012.00240 Text en Copyright © Provart. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Plant Science Provart, Nicholas Correlation networks visualization |
title | Correlation networks visualization |
title_full | Correlation networks visualization |
title_fullStr | Correlation networks visualization |
title_full_unstemmed | Correlation networks visualization |
title_short | Correlation networks visualization |
title_sort | correlation networks visualization |
topic | Plant Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500995/ https://www.ncbi.nlm.nih.gov/pubmed/23181065 http://dx.doi.org/10.3389/fpls.2012.00240 |
work_keys_str_mv | AT provartnicholas correlationnetworksvisualization |