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Elevated SP-1 Transcription Factor Expression and Activity Drives Basal and Hypoxia-induced Vascular Endothelial Growth Factor (VEGF) Expression in Non-Small Cell Lung Cancer

VEGF plays a central role in angiogenesis in cancer. Non-small cell lung cancer (NSCLC) tumors have increased microvascular density, localized hypoxia, and high VEGF expression levels; however, there is a lack of understanding of how oncogenic and tumor microenvironment changes such as hypoxia lead...

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Detalles Bibliográficos
Autores principales:	Deacon, Karl, Onion, David, Kumari, Rajendra, Watson, Susan A., Knox, Alan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Gene Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501049/ https://www.ncbi.nlm.nih.gov/pubmed/22992725 http://dx.doi.org/10.1074/jbc.M112.397042

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