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S1P and the birth of platelets
Recent work has highlighted the multitude of biological functions of sphingosine 1-phosphate (S1P), which include roles in hematopoietic cell trafficking, organization of immune organs, vascular development, and neuroinflammation. Indeed, a functional antagonist of S1P(1) receptor, FTY720/Gilenya, h...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501358/ https://www.ncbi.nlm.nih.gov/pubmed/23166370 http://dx.doi.org/10.1084/jem.20122284 |
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author | Hla, Timothy Galvani, Sylvain Rafii, Shahin Nachman, Ralph |
author_facet | Hla, Timothy Galvani, Sylvain Rafii, Shahin Nachman, Ralph |
author_sort | Hla, Timothy |
collection | PubMed |
description | Recent work has highlighted the multitude of biological functions of sphingosine 1-phosphate (S1P), which include roles in hematopoietic cell trafficking, organization of immune organs, vascular development, and neuroinflammation. Indeed, a functional antagonist of S1P(1) receptor, FTY720/Gilenya, has entered the clinic as a novel therapeutic for multiple sclerosis. In this issue of the JEM, Zhang et al. highlight yet another function of this lipid mediator: thrombopoiesis. The S1P(1) receptor is required for the growth of proplatelet strings in the bloodstream and the shedding of platelets into the circulation. Notably, the sharp gradient of S1P between blood and the interstitial fluids seems to be essential to ensure the production of platelets, and S1P appears to cooperate with the CXCL12–CXCR4 axis. Pharmacologic modulation of the S1P(1) receptor altered circulating platelet numbers acutely, suggesting a potential therapeutic strategy for controlling thrombocytopenic states. However, the S1P(4) receptor may also regulate thrombopoiesis during stress-induced accelerated platelet production. This work reveals a novel physiological action of the S1P/S1P(1) duet that could potentially be harnessed for clinical translation. |
format | Online Article Text |
id | pubmed-3501358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-35013582013-05-19 S1P and the birth of platelets Hla, Timothy Galvani, Sylvain Rafii, Shahin Nachman, Ralph J Exp Med Minireview Recent work has highlighted the multitude of biological functions of sphingosine 1-phosphate (S1P), which include roles in hematopoietic cell trafficking, organization of immune organs, vascular development, and neuroinflammation. Indeed, a functional antagonist of S1P(1) receptor, FTY720/Gilenya, has entered the clinic as a novel therapeutic for multiple sclerosis. In this issue of the JEM, Zhang et al. highlight yet another function of this lipid mediator: thrombopoiesis. The S1P(1) receptor is required for the growth of proplatelet strings in the bloodstream and the shedding of platelets into the circulation. Notably, the sharp gradient of S1P between blood and the interstitial fluids seems to be essential to ensure the production of platelets, and S1P appears to cooperate with the CXCL12–CXCR4 axis. Pharmacologic modulation of the S1P(1) receptor altered circulating platelet numbers acutely, suggesting a potential therapeutic strategy for controlling thrombocytopenic states. However, the S1P(4) receptor may also regulate thrombopoiesis during stress-induced accelerated platelet production. This work reveals a novel physiological action of the S1P/S1P(1) duet that could potentially be harnessed for clinical translation. The Rockefeller University Press 2012-11-19 /pmc/articles/PMC3501358/ /pubmed/23166370 http://dx.doi.org/10.1084/jem.20122284 Text en © 2012 Hla et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Minireview Hla, Timothy Galvani, Sylvain Rafii, Shahin Nachman, Ralph S1P and the birth of platelets |
title | S1P and the birth of platelets |
title_full | S1P and the birth of platelets |
title_fullStr | S1P and the birth of platelets |
title_full_unstemmed | S1P and the birth of platelets |
title_short | S1P and the birth of platelets |
title_sort | s1p and the birth of platelets |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501358/ https://www.ncbi.nlm.nih.gov/pubmed/23166370 http://dx.doi.org/10.1084/jem.20122284 |
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