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S1P and the birth of platelets

Recent work has highlighted the multitude of biological functions of sphingosine 1-phosphate (S1P), which include roles in hematopoietic cell trafficking, organization of immune organs, vascular development, and neuroinflammation. Indeed, a functional antagonist of S1P(1) receptor, FTY720/Gilenya, h...

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Detalles Bibliográficos
Autores principales: Hla, Timothy, Galvani, Sylvain, Rafii, Shahin, Nachman, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501358/
https://www.ncbi.nlm.nih.gov/pubmed/23166370
http://dx.doi.org/10.1084/jem.20122284
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author Hla, Timothy
Galvani, Sylvain
Rafii, Shahin
Nachman, Ralph
author_facet Hla, Timothy
Galvani, Sylvain
Rafii, Shahin
Nachman, Ralph
author_sort Hla, Timothy
collection PubMed
description Recent work has highlighted the multitude of biological functions of sphingosine 1-phosphate (S1P), which include roles in hematopoietic cell trafficking, organization of immune organs, vascular development, and neuroinflammation. Indeed, a functional antagonist of S1P(1) receptor, FTY720/Gilenya, has entered the clinic as a novel therapeutic for multiple sclerosis. In this issue of the JEM, Zhang et al. highlight yet another function of this lipid mediator: thrombopoiesis. The S1P(1) receptor is required for the growth of proplatelet strings in the bloodstream and the shedding of platelets into the circulation. Notably, the sharp gradient of S1P between blood and the interstitial fluids seems to be essential to ensure the production of platelets, and S1P appears to cooperate with the CXCL12–CXCR4 axis. Pharmacologic modulation of the S1P(1) receptor altered circulating platelet numbers acutely, suggesting a potential therapeutic strategy for controlling thrombocytopenic states. However, the S1P(4) receptor may also regulate thrombopoiesis during stress-induced accelerated platelet production. This work reveals a novel physiological action of the S1P/S1P(1) duet that could potentially be harnessed for clinical translation.
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spelling pubmed-35013582013-05-19 S1P and the birth of platelets Hla, Timothy Galvani, Sylvain Rafii, Shahin Nachman, Ralph J Exp Med Minireview Recent work has highlighted the multitude of biological functions of sphingosine 1-phosphate (S1P), which include roles in hematopoietic cell trafficking, organization of immune organs, vascular development, and neuroinflammation. Indeed, a functional antagonist of S1P(1) receptor, FTY720/Gilenya, has entered the clinic as a novel therapeutic for multiple sclerosis. In this issue of the JEM, Zhang et al. highlight yet another function of this lipid mediator: thrombopoiesis. The S1P(1) receptor is required for the growth of proplatelet strings in the bloodstream and the shedding of platelets into the circulation. Notably, the sharp gradient of S1P between blood and the interstitial fluids seems to be essential to ensure the production of platelets, and S1P appears to cooperate with the CXCL12–CXCR4 axis. Pharmacologic modulation of the S1P(1) receptor altered circulating platelet numbers acutely, suggesting a potential therapeutic strategy for controlling thrombocytopenic states. However, the S1P(4) receptor may also regulate thrombopoiesis during stress-induced accelerated platelet production. This work reveals a novel physiological action of the S1P/S1P(1) duet that could potentially be harnessed for clinical translation. The Rockefeller University Press 2012-11-19 /pmc/articles/PMC3501358/ /pubmed/23166370 http://dx.doi.org/10.1084/jem.20122284 Text en © 2012 Hla et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Minireview
Hla, Timothy
Galvani, Sylvain
Rafii, Shahin
Nachman, Ralph
S1P and the birth of platelets
title S1P and the birth of platelets
title_full S1P and the birth of platelets
title_fullStr S1P and the birth of platelets
title_full_unstemmed S1P and the birth of platelets
title_short S1P and the birth of platelets
title_sort s1p and the birth of platelets
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501358/
https://www.ncbi.nlm.nih.gov/pubmed/23166370
http://dx.doi.org/10.1084/jem.20122284
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