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Protective effects of capillary artemisia polysaccharide on oxidative injury to the liver in rats with obstructive jaundice
Obstructive jaundice is a condition caused by blockage of the flow of bile out of the liver. This results in an overflow of bile and its by-products into the blood, and bile excretion from the body is incomplete. Untreated, obstructive jaundice can lead to serious infection that spreads to other par...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501433/ https://www.ncbi.nlm.nih.gov/pubmed/23170119 http://dx.doi.org/10.3892/etm.2012.666 |
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author | HE, CHANG-SHENG YUE, HONG-YI XU, JIAN XUE, FENG LIU, JIAN LI, YUAN-YUAN JING, HONG-EN |
author_facet | HE, CHANG-SHENG YUE, HONG-YI XU, JIAN XUE, FENG LIU, JIAN LI, YUAN-YUAN JING, HONG-EN |
author_sort | HE, CHANG-SHENG |
collection | PubMed |
description | Obstructive jaundice is a condition caused by blockage of the flow of bile out of the liver. This results in an overflow of bile and its by-products into the blood, and bile excretion from the body is incomplete. Untreated, obstructive jaundice can lead to serious infection that spreads to other parts of the body. We examined the protective effect of capillary artemisia polysaccharide on oxidative damage to the liver in growing rats with obstructive jaundice (OJ). Growing male Wistar rats (n=40, age 3–4 weeks) were randomly divided into four groups (n=10 in each group): normal control group, sham group, OJ group and OJ with capillary artimesia polysaccha-ride treatment group (study group). The rats of the OJ group and the study group were subjected to common bile dust ligation, while the sham group had the bile duct mobilized but not ligated. The rats of the study group recieved 5 ml/kg capillary artimesia polysaccharide (0.5 g/ml) by intraperitoneal (i.p.) injection once daily while the other groups were administered 5 ml/kg saline by i.p. injection. After 4 weeks, the rats were sacrificed to obtain liver weight and to compute the liver coefficient. Additional measures included liver homogenate malondialdehyde (MDA) and the activity levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT). The liver weight and liver coefficient of rats in the study group were lower than those in the OJ group and higher than those in the control and sham groups (P<0.05). Liver homogenate MDA content in the study group rats was lower than that in the OJ group and higher than that in the control and sham group (P<0.05). SOD, GSH-Px and CAT activities were higher in the study group rats than those in the OJ group and lower than those in other groups (P<0.05). Capillary artimesia capillary artemisia polysaccharide protects the liver from oxidative damage and improves antioxidant defense in growing rats with obstructive jaundice. |
format | Online Article Text |
id | pubmed-3501433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-35014332013-10-01 Protective effects of capillary artemisia polysaccharide on oxidative injury to the liver in rats with obstructive jaundice HE, CHANG-SHENG YUE, HONG-YI XU, JIAN XUE, FENG LIU, JIAN LI, YUAN-YUAN JING, HONG-EN Exp Ther Med Articles Obstructive jaundice is a condition caused by blockage of the flow of bile out of the liver. This results in an overflow of bile and its by-products into the blood, and bile excretion from the body is incomplete. Untreated, obstructive jaundice can lead to serious infection that spreads to other parts of the body. We examined the protective effect of capillary artemisia polysaccharide on oxidative damage to the liver in growing rats with obstructive jaundice (OJ). Growing male Wistar rats (n=40, age 3–4 weeks) were randomly divided into four groups (n=10 in each group): normal control group, sham group, OJ group and OJ with capillary artimesia polysaccha-ride treatment group (study group). The rats of the OJ group and the study group were subjected to common bile dust ligation, while the sham group had the bile duct mobilized but not ligated. The rats of the study group recieved 5 ml/kg capillary artimesia polysaccharide (0.5 g/ml) by intraperitoneal (i.p.) injection once daily while the other groups were administered 5 ml/kg saline by i.p. injection. After 4 weeks, the rats were sacrificed to obtain liver weight and to compute the liver coefficient. Additional measures included liver homogenate malondialdehyde (MDA) and the activity levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT). The liver weight and liver coefficient of rats in the study group were lower than those in the OJ group and higher than those in the control and sham groups (P<0.05). Liver homogenate MDA content in the study group rats was lower than that in the OJ group and higher than that in the control and sham group (P<0.05). SOD, GSH-Px and CAT activities were higher in the study group rats than those in the OJ group and lower than those in other groups (P<0.05). Capillary artimesia capillary artemisia polysaccharide protects the liver from oxidative damage and improves antioxidant defense in growing rats with obstructive jaundice. D.A. Spandidos 2012-10 2012-08-14 /pmc/articles/PMC3501433/ /pubmed/23170119 http://dx.doi.org/10.3892/etm.2012.666 Text en Copyright © 2012, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles HE, CHANG-SHENG YUE, HONG-YI XU, JIAN XUE, FENG LIU, JIAN LI, YUAN-YUAN JING, HONG-EN Protective effects of capillary artemisia polysaccharide on oxidative injury to the liver in rats with obstructive jaundice |
title | Protective effects of capillary artemisia polysaccharide on oxidative injury to the liver in rats with obstructive jaundice |
title_full | Protective effects of capillary artemisia polysaccharide on oxidative injury to the liver in rats with obstructive jaundice |
title_fullStr | Protective effects of capillary artemisia polysaccharide on oxidative injury to the liver in rats with obstructive jaundice |
title_full_unstemmed | Protective effects of capillary artemisia polysaccharide on oxidative injury to the liver in rats with obstructive jaundice |
title_short | Protective effects of capillary artemisia polysaccharide on oxidative injury to the liver in rats with obstructive jaundice |
title_sort | protective effects of capillary artemisia polysaccharide on oxidative injury to the liver in rats with obstructive jaundice |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501433/ https://www.ncbi.nlm.nih.gov/pubmed/23170119 http://dx.doi.org/10.3892/etm.2012.666 |
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