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Differential Deactivation during Mentalizing and Classification of Autism Based on Default Mode Network Connectivity

The default mode network (DMN) is a collection of brain areas found to be consistently deactivated during task performance. Previous neuroimaging studies of resting state have revealed reduced task-related deactivation of this network in autism. We investigated the DMN in 13 high-functioning adults...

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Autores principales: Murdaugh, Donna L., Shinkareva, Svetlana V., Deshpande, Hrishikesh R., Wang, Jing, Pennick, Mark R., Kana, Rajesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501481/
https://www.ncbi.nlm.nih.gov/pubmed/23185536
http://dx.doi.org/10.1371/journal.pone.0050064
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author Murdaugh, Donna L.
Shinkareva, Svetlana V.
Deshpande, Hrishikesh R.
Wang, Jing
Pennick, Mark R.
Kana, Rajesh K.
author_facet Murdaugh, Donna L.
Shinkareva, Svetlana V.
Deshpande, Hrishikesh R.
Wang, Jing
Pennick, Mark R.
Kana, Rajesh K.
author_sort Murdaugh, Donna L.
collection PubMed
description The default mode network (DMN) is a collection of brain areas found to be consistently deactivated during task performance. Previous neuroimaging studies of resting state have revealed reduced task-related deactivation of this network in autism. We investigated the DMN in 13 high-functioning adults with autism spectrum disorders (ASD) and 14 typically developing control participants during three fMRI studies (two language tasks and a Theory-of-Mind (ToM) task). Each study had separate blocks of fixation/resting baseline. The data from the task blocks and fixation blocks were collated to examine deactivation and functional connectivity. Deficits in the deactivation of the DMN in individuals with ASD were specific only to the ToM task, with no group differences in deactivation during the language tasks or a combined language and self-other discrimination task. During rest blocks following the ToM task, the ASD group showed less deactivation than the control group in a number of DMN regions, including medial prefrontal cortex (MPFC), anterior cingulate cortex, and posterior cingulate gyrus/precuneus. In addition, we found weaker functional connectivity of the MPFC in individuals with ASD compared to controls. Furthermore, we were able to reliably classify participants into ASD or typically developing control groups based on both the whole-brain and seed-based connectivity patterns with accuracy up to 96.3%. These findings indicate that deactivation and connectivity of the DMN were altered in individuals with ASD. In addition, these findings suggest that the deficits in DMN connectivity could be a neural signature that can be used for classifying an individual as belonging to the ASD group.
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spelling pubmed-35014812012-11-26 Differential Deactivation during Mentalizing and Classification of Autism Based on Default Mode Network Connectivity Murdaugh, Donna L. Shinkareva, Svetlana V. Deshpande, Hrishikesh R. Wang, Jing Pennick, Mark R. Kana, Rajesh K. PLoS One Research Article The default mode network (DMN) is a collection of brain areas found to be consistently deactivated during task performance. Previous neuroimaging studies of resting state have revealed reduced task-related deactivation of this network in autism. We investigated the DMN in 13 high-functioning adults with autism spectrum disorders (ASD) and 14 typically developing control participants during three fMRI studies (two language tasks and a Theory-of-Mind (ToM) task). Each study had separate blocks of fixation/resting baseline. The data from the task blocks and fixation blocks were collated to examine deactivation and functional connectivity. Deficits in the deactivation of the DMN in individuals with ASD were specific only to the ToM task, with no group differences in deactivation during the language tasks or a combined language and self-other discrimination task. During rest blocks following the ToM task, the ASD group showed less deactivation than the control group in a number of DMN regions, including medial prefrontal cortex (MPFC), anterior cingulate cortex, and posterior cingulate gyrus/precuneus. In addition, we found weaker functional connectivity of the MPFC in individuals with ASD compared to controls. Furthermore, we were able to reliably classify participants into ASD or typically developing control groups based on both the whole-brain and seed-based connectivity patterns with accuracy up to 96.3%. These findings indicate that deactivation and connectivity of the DMN were altered in individuals with ASD. In addition, these findings suggest that the deficits in DMN connectivity could be a neural signature that can be used for classifying an individual as belonging to the ASD group. Public Library of Science 2012-11-19 /pmc/articles/PMC3501481/ /pubmed/23185536 http://dx.doi.org/10.1371/journal.pone.0050064 Text en © 2012 Murdaugh et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Murdaugh, Donna L.
Shinkareva, Svetlana V.
Deshpande, Hrishikesh R.
Wang, Jing
Pennick, Mark R.
Kana, Rajesh K.
Differential Deactivation during Mentalizing and Classification of Autism Based on Default Mode Network Connectivity
title Differential Deactivation during Mentalizing and Classification of Autism Based on Default Mode Network Connectivity
title_full Differential Deactivation during Mentalizing and Classification of Autism Based on Default Mode Network Connectivity
title_fullStr Differential Deactivation during Mentalizing and Classification of Autism Based on Default Mode Network Connectivity
title_full_unstemmed Differential Deactivation during Mentalizing and Classification of Autism Based on Default Mode Network Connectivity
title_short Differential Deactivation during Mentalizing and Classification of Autism Based on Default Mode Network Connectivity
title_sort differential deactivation during mentalizing and classification of autism based on default mode network connectivity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501481/
https://www.ncbi.nlm.nih.gov/pubmed/23185536
http://dx.doi.org/10.1371/journal.pone.0050064
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