Anti-Diabetic Efficacy and Impact on Amino Acid Metabolism of GRA1, a Novel Small-Molecule Glucagon Receptor Antagonist

Hyperglucagonemia is implicated in the pathophysiology of hyperglycemia. Antagonism of the glucagon receptor (GCGR) thus represents a potential approach to diabetes treatment. Herein we report the characterization of GRA1, a novel small-molecule GCGR antagonist that blocks glucagon binding to the hu...

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Detalles Bibliográficos
Autores principales: Mu, James, Qureshi, Sajjad A., Brady, Edward J., Muise, Eric S., Candelore, Mari Rios, Jiang, Guoqiang, Li, Zhihua, Wu, Margaret S., Yang, Xiaodong, Dallas-Yang, Qing, Miller, Corey, Xiong, Yusheng, Langdon, Ronald B., Parmee, Emma R., Zhang, Bei B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501516/
https://www.ncbi.nlm.nih.gov/pubmed/23185367
http://dx.doi.org/10.1371/journal.pone.0049572

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