Disruption of Growth Factor Receptor–Binding Protein 10 in the Pancreas Enhances β-Cell Proliferation and Protects Mice From Streptozotocin-Induced β-Cell Apoptosis

Defects in insulin secretion and reduction in β-cell mass are associated with type 2 diabetes in humans, and understanding the basis for these dysfunctions may reveal strategies for diabetes therapy. In this study, we show that pancreas-specific knockout of growth factor receptor–binding protein 10...

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Detalles Bibliográficos
Autores principales: Zhang, Jingjing, Zhang, Ning, Liu, Meilian, Li, Xiuling, Zhou, Lijun, Huang, Wei, Xu, Zhipeng, Liu, Jing, Musi, Nicolas, DeFronzo, Ralph A., Cunningham, John M., Zhou, Zhiguang, Lu, Xin-Yun, Liu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501856/
https://www.ncbi.nlm.nih.gov/pubmed/22923474
http://dx.doi.org/10.2337/db12-0249

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