Cargando…

Lipid-Induced Insulin Resistance Is Not Mediated by Impaired Transcapillary Transport of Insulin and Glucose in Humans

Increased lipid availability reduces insulin-stimulated glucose disposal in skeletal muscle, which is generally explained by fatty acid–mediated inhibition of insulin signaling. It remains unclear whether lipids also impair transcapillary transport of insulin and glucose, which could become rate con...

Descripción completa

Detalles Bibliográficos
Autores principales:	Szendroedi, Julia, Frossard, Martin, Klein, Nikolas, Bieglmayer, Christian, Wagner, Oswald, Pacini, Giovanni, Decker, Janette, Nowotny, Peter, Müller, Markus, Roden, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501866/ https://www.ncbi.nlm.nih.gov/pubmed/22891212 http://dx.doi.org/10.2337/db12-0108

Ejemplares similares

Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans
por: Halperin, Florencia, et al.
Publicado: (2012)

Insulin enhances renal glucose excretion: relation to insulin sensitivity and sodium-glucose cotransport
por: Ferrannini, Ele, et al.
Publicado: (2020)

Intraperitoneal insulin administration in pigs: effect on circulating insulin and glucose levels
por: Dirnena-Fusini, Ilze, et al.
Publicado: (2021)

Modelling Transcapillary Transport of Fluid and Proteins in Hemodialysis Patients
por: Pietribiasi, Mauro, et al.
Publicado: (2016)

Insulin Infusion During Normoglycemia Modulates Insulin Secretion According to Whole-Body Insulin Sensitivity
por: Anderwald, Christian, et al.
Publicado: (2011)

Osteocalcin Is Related to Enhanced Insulin Secretion in Gestational Diabetes Mellitus
por: Winhofer, Yvonne, et al.
Publicado: (2010)

Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance
por: Hirvonen, Jussi, et al.
Publicado: (2011)

Dynamics of Transcapillary Fluid Exchange
por: Wiederhielm, Curt A.
Publicado: (1968)

The Ultrastructural Basis of Transcapillary Exchanges
por: Karnovsky, Morris J.
Publicado: (1968)

Transcapillary transport of water, small solutes and proteins during hemodialysis
por: Pstras, Leszek, et al.
Publicado: (2020)

Stimulatory Effect of Insulin on Glucose Uptake by Muscle Involves the Central Nervous System in Insulin-Sensitive Mice
por: Coomans, Claudia P., et al.
Publicado: (2011)

Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans
por: Nowotny, Bettina, et al.
Publicado: (2013)

Transcapillary Exchange in Relation to Capillary Circulation
por: Renkin, Eugene M.
Publicado: (1968)

Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but Not Insulin Action, in High-Fat–Fed Mice
por: Kang, Li, et al.
Publicado: (2014)

Ghrelin Suppresses Glucose-Stimulated Insulin Secretion and Deteriorates Glucose Tolerance in Healthy Humans
por: Tong, Jenny, et al.
Publicado: (2010)

Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling
por: Høeg, Louise D., et al.
Publicado: (2011)

Postexercise Improvement in Insulin-Stimulated Glucose Uptake Occurs Concomitant With Greater AS160 Phosphorylation in Muscle From Normal and Insulin-Resistant Rats
por: Castorena, Carlos M., et al.
Publicado: (2014)

Brain Glucose Sensors Play a Significant Role in the Regulation of Pancreatic Glucose-Stimulated Insulin Secretion
por: Osundiji, Mayowa A., et al.
Publicado: (2012)

Glucose-Dependent Insulinotropic Polypeptide: A Bifunctional Glucose-Dependent Regulator of Glucagon and Insulin Secretion in Humans
por: Christensen, Mikkel, et al.
Publicado: (2011)

Exenatide Sensitizes Insulin-Mediated Whole-Body Glucose Disposal and Promotes Uptake of Exogenous Glucose by the Liver
por: Zheng, Dan, et al.
Publicado: (2009)

Insulin Regulates Hepatic Triglyceride Secretion and Lipid Content via Signaling in the Brain
por: Scherer, Thomas, et al.
Publicado: (2016)

Enhanced Energy Expenditure, Glucose Utilization, and Insulin Sensitivity in VAMP8 Null Mice
por: Zong, Haihong, et al.
Publicado: (2011)

Increased Hepatic Glucose Production in Fetal Sheep With Intrauterine Growth Restriction Is Not Suppressed by Insulin
por: Thorn, Stephanie R., et al.
Publicado: (2013)

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans
por: Chondronikola, Maria, et al.
Publicado: (2014)

GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion
por: Zhang, Hui, et al.
Publicado: (2023)

Diurnal Pattern to Insulin Secretion and Insulin Action in Healthy Individuals
por: Saad, Ahmed, et al.
Publicado: (2012)

Insulin resistance of protein anabolism accompanies that of glucose metabolism in lean, glucose-tolerant offspring of persons with type 2 diabetes
por: Burgos, Sergio A, et al.
Publicado: (2016)

Variability of Directly Measured First-Pass Hepatic Insulin Extraction and Its Association With Insulin Sensitivity and Plasma Insulin
por: Asare-Bediako, Isaac, et al.
Publicado: (2018)

Role of ceramide-to-dihydroceramide ratios for insulin resistance and non-alcoholic fatty liver disease in humans
por: Apostolopoulou, Maria, et al.
Publicado: (2020)

Comprehensive validation of fasting-based and oral glucose tolerance test–based indices of insulin secretion against gold standard measures
por: Prystupa, Katsiaryna, et al.
Publicado: (2022)

Consequences of Lipid Droplet Coat Protein Downregulation in Liver Cells: Abnormal Lipid Droplet Metabolism and Induction of Insulin Resistance
por: Bell, Ming, et al.
Publicado: (2008)

Pharmacological Vasodilation Improves Insulin-Stimulated Muscle Protein Anabolism but Not Glucose Utilization in Older Adults
por: Timmerman, Kyle L., et al.
Publicado: (2010)

Interaction Between the Central and Peripheral Effects of Insulin in Controlling Hepatic Glucose Metabolism in the Conscious Dog
por: Ramnanan, Christopher J., et al.
Publicado: (2013)

Reduced first-phase insulin secretion increases postprandial lipidemia in subjects with impaired glucose tolerance
por: Gómez-Sámano, Miguel Ángel, et al.
Publicado: (2017)

Modulation of Glucose Production by Central Insulin Requires IGF-1 Receptors in AgRP Neurons
por: Farias Quipildor, Gabriela, et al.
Publicado: (2021)

CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action
por: Lord, Caleb C., et al.
Publicado: (2012)

High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance
por: Phielix, Esther, et al.
Publicado: (2012)

Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels
por: Bosma, Madeleen, et al.
Publicado: (2012)

Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling
por: Matveyenko, Aleksey V., et al.
Publicado: (2012)

Whole-Body Insulin Sensitivity Rather than Body-Mass-Index Determines Fasting and Post-Glucose-Load Growth Hormone Concentrations
por: Anderwald, Christian-Heinz, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6h8cp0insq2hvu8kef5d3oa3ii