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Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice

The study herein determined the role of nuclear factor erythoid 2–related factor 2 (Nrf2) in the pathogenesis of hepatic steatosis, insulin resistance, obesity, and type 2 diabetes. Lep(ob/ob)-Keap1-knockdown (KD) mice, which have increased Nrf2 activity, were generated. Markers of obesity and type...

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Detalles Bibliográficos
Autores principales:	Xu, Jialin, Kulkarni, Supriya R., Donepudi, Ajay C., More, Vijay R., Slitt, Angela L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Obesity Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501889/ https://www.ncbi.nlm.nih.gov/pubmed/22936178 http://dx.doi.org/10.2337/db11-1716

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