S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway

Parkinson’s disease is a neurodegenerative disorder that can, at least partly, be mimicked by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. S100B is a calcium-binding protein expressed in, and secreted by, astrocytes. There is increasing evidence that S100B acts as a cytokine or damag...

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Detalles Bibliográficos
Autores principales: Sathe, Kinnari, Maetzler, Walter, Lang, Johannes D., Mounsey, Ross B., Fleckenstein, Corina, Martin, Heather L., Schulte, Claudia, Mustafa, Sarah, Synofzik, Matthis, Vukovic, Zvonimir, Itohara, Shigeyoshi, Berg, Daniela, Teismann, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501971/
https://www.ncbi.nlm.nih.gov/pubmed/23169921
http://dx.doi.org/10.1093/brain/aws250

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