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The non-synonymous SNP, R1150W, in SCN9A is not associated with chronic widespread pain susceptibility

BACKGROUND: Mutations in SCN9A, encoding the alpha subunit of the voltage-gated sodium channel (Na(v)1.7), have caused severe pain disorders and congenital insensitivity to pain. The aim of this study was to validate the previously reported association between a common non-synonymous polymorphism (R...

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Detalles Bibliográficos
Autores principales: Holliday, Kate L, Thomson, Wendy, Neogi, Tuhina, Felson, David T, Wang, Ke, Wu, Frederick C, Huhtaniemi, Ilpo T, Bartfai, Gyorgy, Casanueva, Felipe, Forti, Gianni, Kula, Krzysztof, Punab, Margus, Vanderschueren, Dirk, Macfarlane, Gary J, Horan, Michael A, Ollier, William, Payton, Antony, Pendleton, Neil, McBeth, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502104/
https://www.ncbi.nlm.nih.gov/pubmed/23006801
http://dx.doi.org/10.1186/1744-8069-8-72