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Comparative diagnostic efficacy of serum squamous cell carcinoma antigen in hepatocellular carcinoma
BACKGROUND: Hepatocellular carcinoma (HCC) is a common liver malignancy in Nigeria. Hepatitis B and C viruses, alcohol and Aflatoxin B are among the various aetiologies. More work needs to be done in the search for markers that will aid early detection of this condition as it is uniformly fatal once...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502119/ https://www.ncbi.nlm.nih.gov/pubmed/22856336 http://dx.doi.org/10.1186/1756-0500-5-403 |
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author | Soyemi, Olufemi Michael Otegbayo, Jesse Abiodun Ola, Samuel Olawale Akere, Adegboyega Soyemi, Temitope |
author_facet | Soyemi, Olufemi Michael Otegbayo, Jesse Abiodun Ola, Samuel Olawale Akere, Adegboyega Soyemi, Temitope |
author_sort | Soyemi, Olufemi Michael |
collection | PubMed |
description | BACKGROUND: Hepatocellular carcinoma (HCC) is a common liver malignancy in Nigeria. Hepatitis B and C viruses, alcohol and Aflatoxin B are among the various aetiologies. More work needs to be done in the search for markers that will aid early detection of this condition as it is uniformly fatal once advanced. Alphafetoprotein (AFP) remains the most widely used tumour marker of HCC detection in spite of its known shortcomings. The objective of this study was to determine the efficacy of serum squamous cell carcinoma antigen (SCCA) , in comparison to alphafetoprotein in the detection of HCC. METHOD: Sixty patients with HCC and thirty apparently healthy controls attending the Medical Outpatient Department(MOPD) of the University College Hospital Ibadan(UCH) Nigeria were selected for the study. Questionnaire was used to collect clinical data while AFP, SCCA levels, serum HBsAg and anti-HCV were determined using ELISA method- (Diagnostic Automation Inc. Canada). Abdominal ultrasound scan was also done. RESULT: Thirty one (51.7%) out of 60 selected cases were positive for HBsAg while six (20%) out of 30 controls were positive for HBsAg(p = 0.004). Out of the 60 cases selected for this study, only 2 (3.3.%) cases were positive for hepatitis C virus, while only 1(3.3%) out of 30 control was positive for hepatitis C virus(p = 0.74). The mean AFP value for cases with HCC was 393.21 ng/ml ±386.97 compared to the control group which was 5.60 ± 13.03 ng/ml (p value 0.001). The mean SCCA level was 0.64 ± 0.56 ng/ml and 0.71 ± 0.65 ng/ml for cases and controls respectively (p = 0.631). CONCLUSION: Alphafetoprotein remains a good tumour marker for the diagnosis of HCC. Serum squamous cell carcinoma antigen(SCCA) has no discriminatory power and may not be useful as a tumour marker for Nigerians with hepatocellular carcinoma. |
format | Online Article Text |
id | pubmed-3502119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35021192012-11-21 Comparative diagnostic efficacy of serum squamous cell carcinoma antigen in hepatocellular carcinoma Soyemi, Olufemi Michael Otegbayo, Jesse Abiodun Ola, Samuel Olawale Akere, Adegboyega Soyemi, Temitope BMC Res Notes Research Article BACKGROUND: Hepatocellular carcinoma (HCC) is a common liver malignancy in Nigeria. Hepatitis B and C viruses, alcohol and Aflatoxin B are among the various aetiologies. More work needs to be done in the search for markers that will aid early detection of this condition as it is uniformly fatal once advanced. Alphafetoprotein (AFP) remains the most widely used tumour marker of HCC detection in spite of its known shortcomings. The objective of this study was to determine the efficacy of serum squamous cell carcinoma antigen (SCCA) , in comparison to alphafetoprotein in the detection of HCC. METHOD: Sixty patients with HCC and thirty apparently healthy controls attending the Medical Outpatient Department(MOPD) of the University College Hospital Ibadan(UCH) Nigeria were selected for the study. Questionnaire was used to collect clinical data while AFP, SCCA levels, serum HBsAg and anti-HCV were determined using ELISA method- (Diagnostic Automation Inc. Canada). Abdominal ultrasound scan was also done. RESULT: Thirty one (51.7%) out of 60 selected cases were positive for HBsAg while six (20%) out of 30 controls were positive for HBsAg(p = 0.004). Out of the 60 cases selected for this study, only 2 (3.3.%) cases were positive for hepatitis C virus, while only 1(3.3%) out of 30 control was positive for hepatitis C virus(p = 0.74). The mean AFP value for cases with HCC was 393.21 ng/ml ±386.97 compared to the control group which was 5.60 ± 13.03 ng/ml (p value 0.001). The mean SCCA level was 0.64 ± 0.56 ng/ml and 0.71 ± 0.65 ng/ml for cases and controls respectively (p = 0.631). CONCLUSION: Alphafetoprotein remains a good tumour marker for the diagnosis of HCC. Serum squamous cell carcinoma antigen(SCCA) has no discriminatory power and may not be useful as a tumour marker for Nigerians with hepatocellular carcinoma. BioMed Central 2012-08-03 /pmc/articles/PMC3502119/ /pubmed/22856336 http://dx.doi.org/10.1186/1756-0500-5-403 Text en Copyright ©2012 Soyemi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Soyemi, Olufemi Michael Otegbayo, Jesse Abiodun Ola, Samuel Olawale Akere, Adegboyega Soyemi, Temitope Comparative diagnostic efficacy of serum squamous cell carcinoma antigen in hepatocellular carcinoma |
title | Comparative diagnostic efficacy of serum squamous cell carcinoma antigen in hepatocellular carcinoma |
title_full | Comparative diagnostic efficacy of serum squamous cell carcinoma antigen in hepatocellular carcinoma |
title_fullStr | Comparative diagnostic efficacy of serum squamous cell carcinoma antigen in hepatocellular carcinoma |
title_full_unstemmed | Comparative diagnostic efficacy of serum squamous cell carcinoma antigen in hepatocellular carcinoma |
title_short | Comparative diagnostic efficacy of serum squamous cell carcinoma antigen in hepatocellular carcinoma |
title_sort | comparative diagnostic efficacy of serum squamous cell carcinoma antigen in hepatocellular carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502119/ https://www.ncbi.nlm.nih.gov/pubmed/22856336 http://dx.doi.org/10.1186/1756-0500-5-403 |
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