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The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB(2) receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy

BACKGROUND: Chemotherapeutic agents produce dose-limiting peripheral neuropathy through mechanisms that remain poorly understood. We previously showed that AM1710, a cannabilactone CB(2) agonist, produces antinociception without producing central nervous system (CNS)-associated side effects. The pre...

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Detalles Bibliográficos
Autores principales:	Deng, Liting, Guindon, Josée, Vemuri, V Kiran, Thakur, Ganesh A, White, Fletcher A, Makriyannis, Alexandros, Hohmann, Andrea G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502129/ https://www.ncbi.nlm.nih.gov/pubmed/22998838 http://dx.doi.org/10.1186/1744-8069-8-71

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