Identification of a single base-pair mutation of TAA (Stop codon) → GAA (Glu) that causes light chain extension in a CHO cell derived IgG1

We describe here the identification of a stop codon TAA (Stop) → GAA (Glu) = Stop221E mutation on the light chain of a recombinant IgG1 antibody expressed in a Chinese hamster ovary (CHO) cell line. The extended light chain variants, which were caused by translation beyond the mutated stop codon to...

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Detalles Bibliográficos
Autores principales: Zhang, Taylor, Huang, Yungfu, Chamberlain, Scott, Romeo, Tony, Zhu-Shimoni, Judith, Hewitt, Daniel, Zhu, Mary, Katta, Viswanatham, Mauger, Brad, Kao, Yung-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502236/
https://www.ncbi.nlm.nih.gov/pubmed/23018810
http://dx.doi.org/10.4161/mabs.22232

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