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Some Epidemiologic, Clinical, Microbiologic, and Organizational Assumptions That Influenced the Design and Performance of the Global Enteric Multicenter Study (GEMS)

The overall aim of the Global Enteric Multicenter Study–1 (GEMS-1) is to identify the etiologic agents associated with moderate-to-severe diarrhea (MSD) among children <5 years of age, and thereby the attributable pathogen-specific population-based incidence of MSD, to guide investments in resear...

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Autores principales: Farag, Tamer H., Nasrin, Dilruba, Wu, Yukun, Muhsen, Khitam, Blackwelder, William C., Sommerfelt, Halvor, Panchalingam, Sandra, Nataro, James P., Kotloff, Karen L., Levine, Myron M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502315/
https://www.ncbi.nlm.nih.gov/pubmed/23169935
http://dx.doi.org/10.1093/cid/cis787
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author Farag, Tamer H.
Nasrin, Dilruba
Wu, Yukun
Muhsen, Khitam
Blackwelder, William C.
Sommerfelt, Halvor
Panchalingam, Sandra
Nataro, James P.
Kotloff, Karen L.
Levine, Myron M.
author_facet Farag, Tamer H.
Nasrin, Dilruba
Wu, Yukun
Muhsen, Khitam
Blackwelder, William C.
Sommerfelt, Halvor
Panchalingam, Sandra
Nataro, James P.
Kotloff, Karen L.
Levine, Myron M.
author_sort Farag, Tamer H.
collection PubMed
description The overall aim of the Global Enteric Multicenter Study–1 (GEMS-1) is to identify the etiologic agents associated with moderate-to-severe diarrhea (MSD) among children <5 years of age, and thereby the attributable pathogen-specific population-based incidence of MSD, to guide investments in research and public health interventions against diarrheal disease. To accomplish this, 9 core assumptions were vetted through widespread consultation: (1) a limited number of etiologic agents may be responsible for most MSD; (2) a definition of MSD can be crafted that encompasses cases that might otherwise be fatal in the community without treatment; (3) MSD seen at sentinel centers is a proxy for fatal diarrheal disease in the community; (4) matched case/control is the appropriate epidemiologic design; (5) methods across the sites can be standardized and rigorous quality control maintained; (6) a single 60-day postenrollment visit to case and control households creates mini-cohorts, allowing comparisons; (7) broad support for GEMS-1 messages can be achieved by incorporating advice from public health spokespersons; (8) results will facilitate the setting of investment and intervention priorities; and (9) wide acceptance and dissemination of the GEMS-1 results can be achieved.
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spelling pubmed-35023152012-12-15 Some Epidemiologic, Clinical, Microbiologic, and Organizational Assumptions That Influenced the Design and Performance of the Global Enteric Multicenter Study (GEMS) Farag, Tamer H. Nasrin, Dilruba Wu, Yukun Muhsen, Khitam Blackwelder, William C. Sommerfelt, Halvor Panchalingam, Sandra Nataro, James P. Kotloff, Karen L. Levine, Myron M. Clin Infect Dis Supplement Articles The overall aim of the Global Enteric Multicenter Study–1 (GEMS-1) is to identify the etiologic agents associated with moderate-to-severe diarrhea (MSD) among children <5 years of age, and thereby the attributable pathogen-specific population-based incidence of MSD, to guide investments in research and public health interventions against diarrheal disease. To accomplish this, 9 core assumptions were vetted through widespread consultation: (1) a limited number of etiologic agents may be responsible for most MSD; (2) a definition of MSD can be crafted that encompasses cases that might otherwise be fatal in the community without treatment; (3) MSD seen at sentinel centers is a proxy for fatal diarrheal disease in the community; (4) matched case/control is the appropriate epidemiologic design; (5) methods across the sites can be standardized and rigorous quality control maintained; (6) a single 60-day postenrollment visit to case and control households creates mini-cohorts, allowing comparisons; (7) broad support for GEMS-1 messages can be achieved by incorporating advice from public health spokespersons; (8) results will facilitate the setting of investment and intervention priorities; and (9) wide acceptance and dissemination of the GEMS-1 results can be achieved. Oxford University Press 2012-12-15 /pmc/articles/PMC3502315/ /pubmed/23169935 http://dx.doi.org/10.1093/cid/cis787 Text en © The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Supplement Articles
Farag, Tamer H.
Nasrin, Dilruba
Wu, Yukun
Muhsen, Khitam
Blackwelder, William C.
Sommerfelt, Halvor
Panchalingam, Sandra
Nataro, James P.
Kotloff, Karen L.
Levine, Myron M.
Some Epidemiologic, Clinical, Microbiologic, and Organizational Assumptions That Influenced the Design and Performance of the Global Enteric Multicenter Study (GEMS)
title Some Epidemiologic, Clinical, Microbiologic, and Organizational Assumptions That Influenced the Design and Performance of the Global Enteric Multicenter Study (GEMS)
title_full Some Epidemiologic, Clinical, Microbiologic, and Organizational Assumptions That Influenced the Design and Performance of the Global Enteric Multicenter Study (GEMS)
title_fullStr Some Epidemiologic, Clinical, Microbiologic, and Organizational Assumptions That Influenced the Design and Performance of the Global Enteric Multicenter Study (GEMS)
title_full_unstemmed Some Epidemiologic, Clinical, Microbiologic, and Organizational Assumptions That Influenced the Design and Performance of the Global Enteric Multicenter Study (GEMS)
title_short Some Epidemiologic, Clinical, Microbiologic, and Organizational Assumptions That Influenced the Design and Performance of the Global Enteric Multicenter Study (GEMS)
title_sort some epidemiologic, clinical, microbiologic, and organizational assumptions that influenced the design and performance of the global enteric multicenter study (gems)
topic Supplement Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502315/
https://www.ncbi.nlm.nih.gov/pubmed/23169935
http://dx.doi.org/10.1093/cid/cis787
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