Antifibrotic Effects of Roscovitine in Normal and Scleroderma Fibroblasts

Heightened production of collagen and other matrix proteins underlies the fibrotic phenotype of systemic sclerosis (SSc). Roscovitine is an inhibitor of cyclin-dependent kinases that promote cell cycling (CDK1, 2), neuronal development (CDK5) and control transcription (CDK7,9). In an in vivo glomeru...

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Detalles Bibliográficos
Autores principales: Steinman, Richard A., Robinson, Andria Rasile, Feghali-Bostwick, Carol A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502367/
https://www.ncbi.nlm.nih.gov/pubmed/23185265
http://dx.doi.org/10.1371/journal.pone.0048560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502367/
https://www.ncbi.nlm.nih.gov/pubmed/23185265
http://dx.doi.org/10.1371/journal.pone.0048560

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