Influenza Viral RNA Detection in Blood as a Marker to Predict Disease Severity in Hematopoietic Cell Transplant Recipients

Influenza RNA in blood (viremia) was detected in 9 of 79 (11.4%) hematopoietic cell transplant recipients with influenza, and was less frequently observed in patients with upper respiratory tract disease only and more frequently in patients infected with 2009 pandemic influenza A/H1N1 strain (versus...

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Autores principales: Choi, Su-Mi, Xie, Hu, Campbell, Angela P., Kuypers, Jane, Leisenring, Wendy, Boudreault, Alexandre A., Englund, Janet A., Corey, Lawrence, Boeckh, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502377/
https://www.ncbi.nlm.nih.gov/pubmed/23033148
http://dx.doi.org/10.1093/infdis/jis610
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author Choi, Su-Mi
Xie, Hu
Campbell, Angela P.
Kuypers, Jane
Leisenring, Wendy
Boudreault, Alexandre A.
Englund, Janet A.
Corey, Lawrence
Boeckh, Michael
author_facet Choi, Su-Mi
Xie, Hu
Campbell, Angela P.
Kuypers, Jane
Leisenring, Wendy
Boudreault, Alexandre A.
Englund, Janet A.
Corey, Lawrence
Boeckh, Michael
author_sort Choi, Su-Mi
collection PubMed
description Influenza RNA in blood (viremia) was detected in 9 of 79 (11.4%) hematopoietic cell transplant recipients with influenza, and was less frequently observed in patients with upper respiratory tract disease only and more frequently in patients infected with 2009 pandemic influenza A/H1N1 strain (versus seasonal strains). Viremia increased the risk of progression to lower respiratory tract disease (LRD), hypoxemia, respiratory failure, and overall and influenza-related death. Among patients with LRD, viremia was associated with increased hazards of overall and influenza-associated death (hazard ratio 3.5, 1.1–12). Thus, influenza viremia may serve as marker for overall poor outcome.
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spelling pubmed-35023772013-12-15 Influenza Viral RNA Detection in Blood as a Marker to Predict Disease Severity in Hematopoietic Cell Transplant Recipients Choi, Su-Mi Xie, Hu Campbell, Angela P. Kuypers, Jane Leisenring, Wendy Boudreault, Alexandre A. Englund, Janet A. Corey, Lawrence Boeckh, Michael J Infect Dis Major Articles and Brief Reports Influenza RNA in blood (viremia) was detected in 9 of 79 (11.4%) hematopoietic cell transplant recipients with influenza, and was less frequently observed in patients with upper respiratory tract disease only and more frequently in patients infected with 2009 pandemic influenza A/H1N1 strain (versus seasonal strains). Viremia increased the risk of progression to lower respiratory tract disease (LRD), hypoxemia, respiratory failure, and overall and influenza-related death. Among patients with LRD, viremia was associated with increased hazards of overall and influenza-associated death (hazard ratio 3.5, 1.1–12). Thus, influenza viremia may serve as marker for overall poor outcome. Oxford University Press 2012-12-15 2012-10-02 /pmc/articles/PMC3502377/ /pubmed/23033148 http://dx.doi.org/10.1093/infdis/jis610 Text en © The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Major Articles and Brief Reports
Choi, Su-Mi
Xie, Hu
Campbell, Angela P.
Kuypers, Jane
Leisenring, Wendy
Boudreault, Alexandre A.
Englund, Janet A.
Corey, Lawrence
Boeckh, Michael
Influenza Viral RNA Detection in Blood as a Marker to Predict Disease Severity in Hematopoietic Cell Transplant Recipients
title Influenza Viral RNA Detection in Blood as a Marker to Predict Disease Severity in Hematopoietic Cell Transplant Recipients
title_full Influenza Viral RNA Detection in Blood as a Marker to Predict Disease Severity in Hematopoietic Cell Transplant Recipients
title_fullStr Influenza Viral RNA Detection in Blood as a Marker to Predict Disease Severity in Hematopoietic Cell Transplant Recipients
title_full_unstemmed Influenza Viral RNA Detection in Blood as a Marker to Predict Disease Severity in Hematopoietic Cell Transplant Recipients
title_short Influenza Viral RNA Detection in Blood as a Marker to Predict Disease Severity in Hematopoietic Cell Transplant Recipients
title_sort influenza viral rna detection in blood as a marker to predict disease severity in hematopoietic cell transplant recipients
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502377/
https://www.ncbi.nlm.nih.gov/pubmed/23033148
http://dx.doi.org/10.1093/infdis/jis610
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