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RIN3 Is a Negative Regulator of Mast Cell Responses to SCF

Stimulation of the receptor tyrosine kinase KIT by Stem Cell Factor (SCF) triggers activation of RAS and its downstream effectors. Proper KIT activation is essential for the maturation, survival and proliferation of mast cells. In addition, SCF activation of KIT is critical for recruiting mast cells...

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Detalles Bibliográficos
Autores principales:	Janson, Christine, Kasahara, Noriyuki, Prendergast, George C., Colicelli, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502454/ https://www.ncbi.nlm.nih.gov/pubmed/23185384 http://dx.doi.org/10.1371/journal.pone.0049615

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