Applying Ligands Profiling Using Multiple Extended Electron Distribution Based Field Templates and Feature Trees Similarity Searching in the Discovery of New Generation of Urea-Based Antineoplastic Kinase Inhibitors

This study provides a comprehensive computational procedure for the discovery of novel urea-based antineoplastic kinase inhibitors while focusing on diversification of both chemotype and selectivity pattern. It presents a systematic structural analysis of the different binding motifs of urea-based k...

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Detalles Bibliográficos
Autores principales: Dokla, Eman M., Mahmoud, Amr H., Elsayed, Mohamed S. A., El-Khatib, Ahmed H., Linscheid, Michael W., Abouzid, Khaled A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502486/
https://www.ncbi.nlm.nih.gov/pubmed/23185312
http://dx.doi.org/10.1371/journal.pone.0049284

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