The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas

The HMG-box factor Tcf1 is required during T-cell development in the thymus and mediates the nuclear response to Wnt signals. Tcf1(−/−) mice have previously been characterized and show developmental blocks at the CD4−CD8− double negative (DN) to CD4+CD8+ double positive transition. Due to the blocks...

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Detalles Bibliográficos
Autores principales: Tiemessen, Machteld M., Baert, Miranda R. M., Schonewille, Tom, Brugman, Martijn H., Famili, Farbod, Salvatori, Daniela C. F., Meijerink, Jules P. P., Ozbek, Ugur, Clevers, Hans, van Dongen, Jacques J. M., Staal, Frank J. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502537/
https://www.ncbi.nlm.nih.gov/pubmed/23185135
http://dx.doi.org/10.1371/journal.pbio.1001430

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