Role of Structure-Based Changes due to Somatic Mutation in Highly Homologous DNA-Binding and DNA-Hydrolyzing Autoantibodies Exemplified by A23P Substitution in the VH Domain

Anti-DNA autoantibodies are responsible for tissue injury in lupus. A subset of DNA-specific antibodies capable of DNA cleavage can be even more harmful after entering the living cells by destroying nuclear DNA. Origins of anti-DNA autoantibodies are not fully understood, and the mechanism of induct...

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Detalles Bibliográficos
Autores principales: Kozyr, A. V., Kolesnikov, A. V., Khlyntseva, A. E., Bogun, A. G., Savchenko, G. A., Shemyakin, I. G., Gabibov, A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502752/
https://www.ncbi.nlm.nih.gov/pubmed/23193442
http://dx.doi.org/10.1155/2012/683829

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