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Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors

We have examined the alleles of eleven minor histocompatibility antigens (MiHAs) and investigated the occurrence of immunogenic MiHA disparities in 62 recipients of allogeneic hematopoietic cell transplantation (allo-HCT) with myeloablative conditioning performed between 2000 and 2008 and in their H...

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Autores principales: Dzierzak-Mietla, Monika, Markiewicz, M., Siekiera, Urszula, Mizia, Sylwia, Koclega, Anna, Zielinska, Patrycja, Sobczyk-Kruszelnicka, Malgorzata, Kyrcz-Krzemien, Slawomira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502767/
https://www.ncbi.nlm.nih.gov/pubmed/23193478
http://dx.doi.org/10.1155/2012/257086
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author Dzierzak-Mietla, Monika
Markiewicz, M.
Siekiera, Urszula
Mizia, Sylwia
Koclega, Anna
Zielinska, Patrycja
Sobczyk-Kruszelnicka, Malgorzata
Kyrcz-Krzemien, Slawomira
author_facet Dzierzak-Mietla, Monika
Markiewicz, M.
Siekiera, Urszula
Mizia, Sylwia
Koclega, Anna
Zielinska, Patrycja
Sobczyk-Kruszelnicka, Malgorzata
Kyrcz-Krzemien, Slawomira
author_sort Dzierzak-Mietla, Monika
collection PubMed
description We have examined the alleles of eleven minor histocompatibility antigens (MiHAs) and investigated the occurrence of immunogenic MiHA disparities in 62 recipients of allogeneic hematopoietic cell transplantation (allo-HCT) with myeloablative conditioning performed between 2000 and 2008 and in their HLA-matched sibling donors. Immunogenic MiHA mismatches were detected in 42 donor-recipient pairs: in 29% MiHA was mismatched in HVG direction, in another 29% in GVH direction; bidirectional MiHA disparity was detected in 10% and no MiHA mismatches in 32%. Patients with GVH-directed HY mismatches had lower both overall survival and disease-free survival at 3 years than patients with compatible HY; also higher incidence of both severe acute GvHD and extensive chronic GVHD was observed in patients with GVH-directed HY mismatch. On contrary, GVH-directed mismatches of autosomally encoded MiHAs had no negative effect on overall survival. Results of our study help to understand why posttransplant courses of allo-HCT from siblings may vary despite the complete high-resolution HLA matching of a donor and a recipient.
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spelling pubmed-35027672012-11-28 Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors Dzierzak-Mietla, Monika Markiewicz, M. Siekiera, Urszula Mizia, Sylwia Koclega, Anna Zielinska, Patrycja Sobczyk-Kruszelnicka, Malgorzata Kyrcz-Krzemien, Slawomira Bone Marrow Res Clinical Study We have examined the alleles of eleven minor histocompatibility antigens (MiHAs) and investigated the occurrence of immunogenic MiHA disparities in 62 recipients of allogeneic hematopoietic cell transplantation (allo-HCT) with myeloablative conditioning performed between 2000 and 2008 and in their HLA-matched sibling donors. Immunogenic MiHA mismatches were detected in 42 donor-recipient pairs: in 29% MiHA was mismatched in HVG direction, in another 29% in GVH direction; bidirectional MiHA disparity was detected in 10% and no MiHA mismatches in 32%. Patients with GVH-directed HY mismatches had lower both overall survival and disease-free survival at 3 years than patients with compatible HY; also higher incidence of both severe acute GvHD and extensive chronic GVHD was observed in patients with GVH-directed HY mismatch. On contrary, GVH-directed mismatches of autosomally encoded MiHAs had no negative effect on overall survival. Results of our study help to understand why posttransplant courses of allo-HCT from siblings may vary despite the complete high-resolution HLA matching of a donor and a recipient. Hindawi Publishing Corporation 2012 2012-11-08 /pmc/articles/PMC3502767/ /pubmed/23193478 http://dx.doi.org/10.1155/2012/257086 Text en Copyright © 2012 Monika Dzierzak-Mietla et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Dzierzak-Mietla, Monika
Markiewicz, M.
Siekiera, Urszula
Mizia, Sylwia
Koclega, Anna
Zielinska, Patrycja
Sobczyk-Kruszelnicka, Malgorzata
Kyrcz-Krzemien, Slawomira
Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors
title Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors
title_full Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors
title_fullStr Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors
title_full_unstemmed Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors
title_short Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors
title_sort occurrence and impact of minor histocompatibility antigens' disparities on outcomes of hematopoietic stem cell transplantation from hla-matched sibling donors
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502767/
https://www.ncbi.nlm.nih.gov/pubmed/23193478
http://dx.doi.org/10.1155/2012/257086
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