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Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma
Brain metastases arise in 10%–40% of all cancer patients. Up to one third of the patients do not have previous cancer history. We report a case of a 67-years-old male patient who presented with confusion, tremor, and apraxia. A brain MRI revealed an isolated right temporal lobe lesion. A thorax-abdo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502798/ https://www.ncbi.nlm.nih.gov/pubmed/23198200 http://dx.doi.org/10.1155/2012/192807 |
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author | Biroli, Antonio Cecchi, Paolo Cipriano Pragal, Susanne Hanspeter, Esther Schwarz, Andreas |
author_facet | Biroli, Antonio Cecchi, Paolo Cipriano Pragal, Susanne Hanspeter, Esther Schwarz, Andreas |
author_sort | Biroli, Antonio |
collection | PubMed |
description | Brain metastases arise in 10%–40% of all cancer patients. Up to one third of the patients do not have previous cancer history. We report a case of a 67-years-old male patient who presented with confusion, tremor, and apraxia. A brain MRI revealed an isolated right temporal lobe lesion. A thorax-abdomen-pelvis CT scan showed no primary lesion. The patient underwent a craniotomy with gross-total resection. Histopathology revealed an intestinal-type adenocarcinoma. A colonoscopy found no primary lesion, but a PET-CT scan showed elevated FDG uptake in the appendiceal nodule. A right hemicolectomy was performed, and the specimen showed a moderately differentiated mucinous appendiceal adenocarcinoma. Whole brain radiotherapy was administrated. A subsequent thorax-abdomen CT scan revealed multiple lung and hepatic metastasis. Seven months later, the patient died of disease progression. In cases of undiagnosed primary lesions, patients present in better general condition, but overall survival does not change. Eventual identification of the primary tumor does not affect survival. PET/CT might be a helpful tool in detecting lesions of the appendiceal region. To the best of our knowledge, such a case was never reported in the literature, and an appendiceal malignancy should be suspected in patients with brain metastasis from an undiagnosed primary tumor. |
format | Online Article Text |
id | pubmed-3502798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35027982012-11-29 Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma Biroli, Antonio Cecchi, Paolo Cipriano Pragal, Susanne Hanspeter, Esther Schwarz, Andreas Case Rep Oncol Med Case Report Brain metastases arise in 10%–40% of all cancer patients. Up to one third of the patients do not have previous cancer history. We report a case of a 67-years-old male patient who presented with confusion, tremor, and apraxia. A brain MRI revealed an isolated right temporal lobe lesion. A thorax-abdomen-pelvis CT scan showed no primary lesion. The patient underwent a craniotomy with gross-total resection. Histopathology revealed an intestinal-type adenocarcinoma. A colonoscopy found no primary lesion, but a PET-CT scan showed elevated FDG uptake in the appendiceal nodule. A right hemicolectomy was performed, and the specimen showed a moderately differentiated mucinous appendiceal adenocarcinoma. Whole brain radiotherapy was administrated. A subsequent thorax-abdomen CT scan revealed multiple lung and hepatic metastasis. Seven months later, the patient died of disease progression. In cases of undiagnosed primary lesions, patients present in better general condition, but overall survival does not change. Eventual identification of the primary tumor does not affect survival. PET/CT might be a helpful tool in detecting lesions of the appendiceal region. To the best of our knowledge, such a case was never reported in the literature, and an appendiceal malignancy should be suspected in patients with brain metastasis from an undiagnosed primary tumor. Hindawi Publishing Corporation 2012 2012-11-01 /pmc/articles/PMC3502798/ /pubmed/23198200 http://dx.doi.org/10.1155/2012/192807 Text en Copyright © 2012 Antonio Biroli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Biroli, Antonio Cecchi, Paolo Cipriano Pragal, Susanne Hanspeter, Esther Schwarz, Andreas Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma |
title | Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma |
title_full | Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma |
title_fullStr | Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma |
title_full_unstemmed | Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma |
title_short | Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma |
title_sort | cerebral metastasis from a previously undiagnosed appendiceal adenocarcinoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502798/ https://www.ncbi.nlm.nih.gov/pubmed/23198200 http://dx.doi.org/10.1155/2012/192807 |
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