Hypoglycemic Effect of Laminaria japonica Polysaccharide in a Type 2 Diabetes Mellitus Mouse Model

The aim is to investigate the hypoglycemic effect of Laminaria japonica polysaccharides (LJPS) on type 2 diabetes mellitus (T2DM) mice model. 60 healthy male mice have been used in the experiment. T2DM animal mode was prepared by high fatty forage feeding and intraperitoneal injection with alloxan....

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Detalles Bibliográficos
Autores principales: Li, Xiaodan, Yu, Zhuqin, Long, Shaohua, Guo, Yunliang, Duan, Delin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503303/
https://www.ncbi.nlm.nih.gov/pubmed/23209930
http://dx.doi.org/10.5402/2012/507462
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author Li, Xiaodan
Yu, Zhuqin
Long, Shaohua
Guo, Yunliang
Duan, Delin
author_facet Li, Xiaodan
Yu, Zhuqin
Long, Shaohua
Guo, Yunliang
Duan, Delin
author_sort Li, Xiaodan
collection PubMed
description The aim is to investigate the hypoglycemic effect of Laminaria japonica polysaccharides (LJPS) on type 2 diabetes mellitus (T2DM) mice model. 60 healthy male mice have been used in the experiment. T2DM animal mode was prepared by high fatty forage feeding and intraperitoneal injection with alloxan. Diabetic mice were orally supplied with LJPS. Then their blood was collected for various biomedical measurements of fasting blood glucose (FBG), serum insulin, and amylin. Treatment with LJPS significantly reduced fasting blood glucose (P < 0.05) and increased the levels of insulin and amylin in serum (P < 0.05). Overall, the study presented that LJPS can reverse several components of T2DM. Therefore, LJPS may become a new oral candidate medicine for the treatment of diabetes.
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spelling pubmed-35033032012-12-03 Hypoglycemic Effect of Laminaria japonica Polysaccharide in a Type 2 Diabetes Mellitus Mouse Model Li, Xiaodan Yu, Zhuqin Long, Shaohua Guo, Yunliang Duan, Delin ISRN Endocrinol Research Article The aim is to investigate the hypoglycemic effect of Laminaria japonica polysaccharides (LJPS) on type 2 diabetes mellitus (T2DM) mice model. 60 healthy male mice have been used in the experiment. T2DM animal mode was prepared by high fatty forage feeding and intraperitoneal injection with alloxan. Diabetic mice were orally supplied with LJPS. Then their blood was collected for various biomedical measurements of fasting blood glucose (FBG), serum insulin, and amylin. Treatment with LJPS significantly reduced fasting blood glucose (P < 0.05) and increased the levels of insulin and amylin in serum (P < 0.05). Overall, the study presented that LJPS can reverse several components of T2DM. Therefore, LJPS may become a new oral candidate medicine for the treatment of diabetes. International Scholarly Research Network 2012-10-30 /pmc/articles/PMC3503303/ /pubmed/23209930 http://dx.doi.org/10.5402/2012/507462 Text en Copyright © 2012 Xiaodan Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Xiaodan
Yu, Zhuqin
Long, Shaohua
Guo, Yunliang
Duan, Delin
Hypoglycemic Effect of Laminaria japonica Polysaccharide in a Type 2 Diabetes Mellitus Mouse Model
title Hypoglycemic Effect of Laminaria japonica Polysaccharide in a Type 2 Diabetes Mellitus Mouse Model
title_full Hypoglycemic Effect of Laminaria japonica Polysaccharide in a Type 2 Diabetes Mellitus Mouse Model
title_fullStr Hypoglycemic Effect of Laminaria japonica Polysaccharide in a Type 2 Diabetes Mellitus Mouse Model
title_full_unstemmed Hypoglycemic Effect of Laminaria japonica Polysaccharide in a Type 2 Diabetes Mellitus Mouse Model
title_short Hypoglycemic Effect of Laminaria japonica Polysaccharide in a Type 2 Diabetes Mellitus Mouse Model
title_sort hypoglycemic effect of laminaria japonica polysaccharide in a type 2 diabetes mellitus mouse model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503303/
https://www.ncbi.nlm.nih.gov/pubmed/23209930
http://dx.doi.org/10.5402/2012/507462
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