Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats

Exposure to hypobaric hypoxia causes oxidative damage to male rat reproductive function. The aim of this study was to evaluate the protective effect of a blueberry extract (BB-4) in testis of rats exposed to hypobaric hypoxia. Morphometric analysis, cellular DNA fragmentation, glutathione reductase...

Descripción completa

Detalles Bibliográficos
Autores principales: Zepeda, Andrea, Aguayo, Luis G., Fuentealba, Jorge, Figueroa, Carolina, Acevedo, Alejandro, Salgado, Perla, Calaf, Gloria M., Farías, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503460/
https://www.ncbi.nlm.nih.gov/pubmed/23213351
http://dx.doi.org/10.1155/2012/975870
_version_ 1782250449064165376
author Zepeda, Andrea
Aguayo, Luis G.
Fuentealba, Jorge
Figueroa, Carolina
Acevedo, Alejandro
Salgado, Perla
Calaf, Gloria M.
Farías, Jorge
author_facet Zepeda, Andrea
Aguayo, Luis G.
Fuentealba, Jorge
Figueroa, Carolina
Acevedo, Alejandro
Salgado, Perla
Calaf, Gloria M.
Farías, Jorge
author_sort Zepeda, Andrea
collection PubMed
description Exposure to hypobaric hypoxia causes oxidative damage to male rat reproductive function. The aim of this study was to evaluate the protective effect of a blueberry extract (BB-4) in testis of rats exposed to hypobaric hypoxia. Morphometric analysis, cellular DNA fragmentation, glutathione reductase (GR), and superoxide dismutase (SOD) activities were evaluated. Our results showed that supplementation of BB-4 reduced lipid peroxidation, decreased apoptosis, and increased GR and SOD activities in rat testis under hypobaric hypoxia conditions (P < 0.05). Therefore, this study demonstrates that blueberry extract significantly reduced the harmful effects of oxidative stress caused by hypobaric hypoxia in rat testis by affecting glutathione reductase and superoxide dismutase activities.
format Online
Article
Text
id pubmed-3503460
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-35034602012-12-04 Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats Zepeda, Andrea Aguayo, Luis G. Fuentealba, Jorge Figueroa, Carolina Acevedo, Alejandro Salgado, Perla Calaf, Gloria M. Farías, Jorge Oxid Med Cell Longev Research Article Exposure to hypobaric hypoxia causes oxidative damage to male rat reproductive function. The aim of this study was to evaluate the protective effect of a blueberry extract (BB-4) in testis of rats exposed to hypobaric hypoxia. Morphometric analysis, cellular DNA fragmentation, glutathione reductase (GR), and superoxide dismutase (SOD) activities were evaluated. Our results showed that supplementation of BB-4 reduced lipid peroxidation, decreased apoptosis, and increased GR and SOD activities in rat testis under hypobaric hypoxia conditions (P < 0.05). Therefore, this study demonstrates that blueberry extract significantly reduced the harmful effects of oxidative stress caused by hypobaric hypoxia in rat testis by affecting glutathione reductase and superoxide dismutase activities. Hindawi Publishing Corporation 2012 2012-10-31 /pmc/articles/PMC3503460/ /pubmed/23213351 http://dx.doi.org/10.1155/2012/975870 Text en Copyright © 2012 Andrea Zepeda et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zepeda, Andrea
Aguayo, Luis G.
Fuentealba, Jorge
Figueroa, Carolina
Acevedo, Alejandro
Salgado, Perla
Calaf, Gloria M.
Farías, Jorge
Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats
title Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats
title_full Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats
title_fullStr Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats
title_full_unstemmed Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats
title_short Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats
title_sort blueberry extracts protect testis from hypobaric hypoxia induced oxidative stress in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503460/
https://www.ncbi.nlm.nih.gov/pubmed/23213351
http://dx.doi.org/10.1155/2012/975870
work_keys_str_mv AT zepedaandrea blueberryextractsprotecttestisfromhypobarichypoxiainducedoxidativestressinrats
AT aguayoluisg blueberryextractsprotecttestisfromhypobarichypoxiainducedoxidativestressinrats
AT fuentealbajorge blueberryextractsprotecttestisfromhypobarichypoxiainducedoxidativestressinrats
AT figueroacarolina blueberryextractsprotecttestisfromhypobarichypoxiainducedoxidativestressinrats
AT acevedoalejandro blueberryextractsprotecttestisfromhypobarichypoxiainducedoxidativestressinrats
AT salgadoperla blueberryextractsprotecttestisfromhypobarichypoxiainducedoxidativestressinrats
AT calafgloriam blueberryextractsprotecttestisfromhypobarichypoxiainducedoxidativestressinrats
AT fariasjorge blueberryextractsprotecttestisfromhypobarichypoxiainducedoxidativestressinrats

Ejemplares similares