Cargando…

CXCL12/CXCR4 axis plays pivotal roles in the organ-specific metastasis of pancreatic adenocarcinoma: A clinical study

Pancreatic cancer is one of the most lethal types of cancer, and curative resection is only applicable to potentially limited cases due to early metastasis and local invasion. This study reports the influence of CXCL12 and its receptor CXCR4 on the progression of pancreatic cancer and highlights the...

Descripción completa

Detalles Bibliográficos
Autores principales: ZHONG, WEIXIA, CHEN, WEIWEI, ZHANG, DEXIAN, SUN, JUJIE, LI, YUHUI, ZHANG, JIANBO, GAO, YONGSHENG, ZHOU, WUYUAN, LI, SHENG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503540/
https://www.ncbi.nlm.nih.gov/pubmed/23181100
http://dx.doi.org/10.3892/etm.2012.631
_version_ 1782250456389517312
author ZHONG, WEIXIA
CHEN, WEIWEI
ZHANG, DEXIAN
SUN, JUJIE
LI, YUHUI
ZHANG, JIANBO
GAO, YONGSHENG
ZHOU, WUYUAN
LI, SHENG
author_facet ZHONG, WEIXIA
CHEN, WEIWEI
ZHANG, DEXIAN
SUN, JUJIE
LI, YUHUI
ZHANG, JIANBO
GAO, YONGSHENG
ZHOU, WUYUAN
LI, SHENG
author_sort ZHONG, WEIXIA
collection PubMed
description Pancreatic cancer is one of the most lethal types of cancer, and curative resection is only applicable to potentially limited cases due to early metastasis and local invasion. This study reports the influence of CXCL12 and its receptor CXCR4 on the progression of pancreatic cancer and highlights the correlation between the CXCL12/CXCR4 axis and the organ-specific metastasis of pancreatic adenocarcinoma (PAC). A total of 34 patients with pancreatic cancer participated in the current study. The expression of CXCL12 and CXCR4 in cancerous tissues, paracancerous tissues, normal pancreas and lymph nodes surrounding the pancreas were investigated using immunohistochemistry and RT-PCR; furthermore, their relationship with clinicopathological factors was explored (PV9000 method). The positive rate of CXCL12 protein was 13.3% (4/30), the positive rate of CXCR4 protein was 80% (24/30) in tumor tissues. Additionally, a significant correlation between the expression pattern of the CXCL12/CXCR4 axis with lymph node metastasis was identified (P<0.05), excluding gender, age, tumor node metastasis (TNM) stage and differentiation (all P>0.05). Also, the positive rate of CXCL12 protein was 50% (15/30), the positive rate of CXCR4 protein was 73.3% (22/30) in the lymphocytes in lymph nodes surrounding the pancreas. Furthermore, we found that CXCL12 and CXCR4 expression in paratumorous vessels and neural tissue were significantly strongly positive. The paratumorous vessels and neural tissue with positive CXCL12 and CXCR4 expression were invaded by CXCL12-positive pancreatic cancer cells. The chemotactic interaction between CXCR4 and its ligand CXCL12 may be a critical event during the progression of pancreatic cancer. The CXCL12/CXCR4 axis plays an important role in the progression and organ-specific metastasis of pancreatic adenocarcinoma.
format Online
Article
Text
id pubmed-3503540
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-35035402013-09-01 CXCL12/CXCR4 axis plays pivotal roles in the organ-specific metastasis of pancreatic adenocarcinoma: A clinical study ZHONG, WEIXIA CHEN, WEIWEI ZHANG, DEXIAN SUN, JUJIE LI, YUHUI ZHANG, JIANBO GAO, YONGSHENG ZHOU, WUYUAN LI, SHENG Exp Ther Med Articles Pancreatic cancer is one of the most lethal types of cancer, and curative resection is only applicable to potentially limited cases due to early metastasis and local invasion. This study reports the influence of CXCL12 and its receptor CXCR4 on the progression of pancreatic cancer and highlights the correlation between the CXCL12/CXCR4 axis and the organ-specific metastasis of pancreatic adenocarcinoma (PAC). A total of 34 patients with pancreatic cancer participated in the current study. The expression of CXCL12 and CXCR4 in cancerous tissues, paracancerous tissues, normal pancreas and lymph nodes surrounding the pancreas were investigated using immunohistochemistry and RT-PCR; furthermore, their relationship with clinicopathological factors was explored (PV9000 method). The positive rate of CXCL12 protein was 13.3% (4/30), the positive rate of CXCR4 protein was 80% (24/30) in tumor tissues. Additionally, a significant correlation between the expression pattern of the CXCL12/CXCR4 axis with lymph node metastasis was identified (P<0.05), excluding gender, age, tumor node metastasis (TNM) stage and differentiation (all P>0.05). Also, the positive rate of CXCL12 protein was 50% (15/30), the positive rate of CXCR4 protein was 73.3% (22/30) in the lymphocytes in lymph nodes surrounding the pancreas. Furthermore, we found that CXCL12 and CXCR4 expression in paratumorous vessels and neural tissue were significantly strongly positive. The paratumorous vessels and neural tissue with positive CXCL12 and CXCR4 expression were invaded by CXCL12-positive pancreatic cancer cells. The chemotactic interaction between CXCR4 and its ligand CXCL12 may be a critical event during the progression of pancreatic cancer. The CXCL12/CXCR4 axis plays an important role in the progression and organ-specific metastasis of pancreatic adenocarcinoma. D.A. Spandidos 2012-09 2012-07-04 /pmc/articles/PMC3503540/ /pubmed/23181100 http://dx.doi.org/10.3892/etm.2012.631 Text en Copyright © 2012, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
ZHONG, WEIXIA
CHEN, WEIWEI
ZHANG, DEXIAN
SUN, JUJIE
LI, YUHUI
ZHANG, JIANBO
GAO, YONGSHENG
ZHOU, WUYUAN
LI, SHENG
CXCL12/CXCR4 axis plays pivotal roles in the organ-specific metastasis of pancreatic adenocarcinoma: A clinical study
title CXCL12/CXCR4 axis plays pivotal roles in the organ-specific metastasis of pancreatic adenocarcinoma: A clinical study
title_full CXCL12/CXCR4 axis plays pivotal roles in the organ-specific metastasis of pancreatic adenocarcinoma: A clinical study
title_fullStr CXCL12/CXCR4 axis plays pivotal roles in the organ-specific metastasis of pancreatic adenocarcinoma: A clinical study
title_full_unstemmed CXCL12/CXCR4 axis plays pivotal roles in the organ-specific metastasis of pancreatic adenocarcinoma: A clinical study
title_short CXCL12/CXCR4 axis plays pivotal roles in the organ-specific metastasis of pancreatic adenocarcinoma: A clinical study
title_sort cxcl12/cxcr4 axis plays pivotal roles in the organ-specific metastasis of pancreatic adenocarcinoma: a clinical study
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503540/
https://www.ncbi.nlm.nih.gov/pubmed/23181100
http://dx.doi.org/10.3892/etm.2012.631
work_keys_str_mv AT zhongweixia cxcl12cxcr4axisplayspivotalrolesintheorganspecificmetastasisofpancreaticadenocarcinomaaclinicalstudy
AT chenweiwei cxcl12cxcr4axisplayspivotalrolesintheorganspecificmetastasisofpancreaticadenocarcinomaaclinicalstudy
AT zhangdexian cxcl12cxcr4axisplayspivotalrolesintheorganspecificmetastasisofpancreaticadenocarcinomaaclinicalstudy
AT sunjujie cxcl12cxcr4axisplayspivotalrolesintheorganspecificmetastasisofpancreaticadenocarcinomaaclinicalstudy
AT liyuhui cxcl12cxcr4axisplayspivotalrolesintheorganspecificmetastasisofpancreaticadenocarcinomaaclinicalstudy
AT zhangjianbo cxcl12cxcr4axisplayspivotalrolesintheorganspecificmetastasisofpancreaticadenocarcinomaaclinicalstudy
AT gaoyongsheng cxcl12cxcr4axisplayspivotalrolesintheorganspecificmetastasisofpancreaticadenocarcinomaaclinicalstudy
AT zhouwuyuan cxcl12cxcr4axisplayspivotalrolesintheorganspecificmetastasisofpancreaticadenocarcinomaaclinicalstudy
AT lisheng cxcl12cxcr4axisplayspivotalrolesintheorganspecificmetastasisofpancreaticadenocarcinomaaclinicalstudy