Mitigating an undesirable immune response of inherent susceptibility to cutaneous leishmaniosis in a mouse model: the role of the pathoantigenic HISA70 DNA vaccine

Leishmania major is the major cause of cutaneous leishmaniosis (CL) outside of the Americas. In the present study we have cloned six Leishmania genes (H2A, H2B, H3, H4, A2 and HSP70) into the eukaryotic expression vector pCMVβ-m2a, resulting in pCMV-HISA70m2A, which encodes all six pathoantigenic pr...

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Detalles Bibliográficos
Autores principales: Domínguez-Bernal, Gustavo, Horcajo, Pilar, Orden, José A, De La Fuente, Ricardo, Herrero-Gil, Aldara, Ordóñez-Gutiérrez, Lara, Carrión, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503552/
https://www.ncbi.nlm.nih.gov/pubmed/22876751
http://dx.doi.org/10.1186/1297-9716-43-59

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