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Anti-Myeloma Activity of Akt Inhibition Is Linked to the Activation Status of PI3K/Akt and MEK/ERK Pathway

The PI3K/Akt/mTOR signal transduction pathway plays a central role in multiple myeloma (MM) disease progression and development of therapeutic resistance. mTORC1 inhibitors have shown limited efficacy in the clinic, largely attributed to the reactivation of Akt due to rapamycin induced mTORC2 activi...

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Detalles Bibliográficos
Autores principales:	Ramakrishnan, Vijay, Kimlinger, Teresa, Haug, Jessica, Painuly, Utkarsh, Wellik, Linda, Halling, Timothy, Rajkumar, S. Vincent, Kumar, Shaji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503708/ https://www.ncbi.nlm.nih.gov/pubmed/23185517 http://dx.doi.org/10.1371/journal.pone.0050005

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