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Limits of Ligand Selectivity from Docking to Models: In Silico Screening for A(1) Adenosine Receptor Antagonists

G protein-coupled receptors (GPCRs) are attractive targets for pharmaceutical research. With the recent determination of several GPCR X-ray structures, the applicability of structure-based computational methods for ligand identification, such as docking, has increased. Yet, as only about 1% of GPCRs...

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Detalles Bibliográficos
Autores principales:	Kolb, Peter, Phan, Khai, Gao, Zhan-Guo, Marko, Adam C., Sali, Andrej, Jacobson, Kenneth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503826/ https://www.ncbi.nlm.nih.gov/pubmed/23185482 http://dx.doi.org/10.1371/journal.pone.0049910

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