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Engineering Escherichia coli to increase plasmid DNA production in high cell-density cultivations in batch mode

BACKGROUND: Plasmid DNA (pDNA) is a promising molecule for therapeutic applications. pDNA is produced by Escherichia coli in high cell-density cultivations (HCDC) using fed-batch mode. The typical limitations of such cultivations, including metabolic deviations like aerobic acetate production due to...

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Detalles Bibliográficos
Autores principales:	Borja, Gheorghe M, Meza Mora, Eugenio, Barrón, Blanca, Gosset, Guillermo, Ramírez, Octavio T, Lara, Alvaro R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503842/ https://www.ncbi.nlm.nih.gov/pubmed/22992433 http://dx.doi.org/10.1186/1475-2859-11-132

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