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The Full Capacity of AICAR to Reduce Obesity-Induced Inflammation and Insulin Resistance Requires Myeloid SIRT1

Chronic Inflammation is a key link between obesity and insulin resistance. We previously showed that two nutrient sensors AMP-activated protein kinase (AMPK) and SIRT1 interact to regulate macrophage inflammation. AMPK is also a molecular target of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside...

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Detalles Bibliográficos
Autores principales:	Yang, Zhenggang, Wang, Xianfeng, He, Yin, Qi, Ling, Yu, Liqing, Xue, Bingzhong, Shi, Hang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503857/ https://www.ncbi.nlm.nih.gov/pubmed/23183898 http://dx.doi.org/10.1371/journal.pone.0049935

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