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Cerebrospinal Fluid Matrix Metalloproteinases Are Elevated in Cerebral Adrenoleukodystrophy and Correlate with MRI Severity and Neurologic Dysfunction

BACKGROUND: X-linked adrenoleukodystrophy results from mutations in the ABCD1 gene disrupting the metabolism of very-long-chain fatty acids. The most serious form of ALD, cerebral adrenoleukodystrophy (cALD), causes neuroinflammation and demyelination. Neuroimaging in cALD shows inflammatory changes...

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Detalles Bibliográficos
Autores principales:	Thibert, Kathryn A., Raymond, Gerald V., Nascene, David R., Miller, Weston P., Tolar, Jakub, Orchard, Paul J., Lund, Troy C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503955/ https://www.ncbi.nlm.nih.gov/pubmed/23185624 http://dx.doi.org/10.1371/journal.pone.0050430

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