Alterations in Cellular Energy Metabolism Associated with the Antiproliferative Effects of the ATM Inhibitor KU-55933 and with Metformin

KU-55933 is a specific inhibitor of the kinase activity of the protein encoded by Ataxia telangiectasia mutated (ATM), an important tumor suppressor gene with key roles in DNA repair. Unexpectedly for an inhibitor of a tumor suppressor gene, KU-55933 reduces proliferation. In view of prior prelimina...

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Detalles Bibliográficos
Autores principales: Zakikhani, Mahvash, Bazile, Miguel, Hashemi, Sina, Javeshghani, Shiva, Avizonis, Daina, Pierre, Julie St, Pollak, Michael N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504012/
https://www.ncbi.nlm.nih.gov/pubmed/23185347
http://dx.doi.org/10.1371/journal.pone.0049513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504012/
https://www.ncbi.nlm.nih.gov/pubmed/23185347
http://dx.doi.org/10.1371/journal.pone.0049513

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