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Botulinum Neurotoxin Serotype a Specific Cell-Based Potency Assay to Replace the Mouse Bioassay

Botulinum neurotoxin serotype A (BoNT/A), a potent therapeutic used to treat various disorders, inhibits vesicular neurotransmitter exocytosis by cleaving SNAP25. Development of cell-based potency assays (CBPAs) to assess the biological function of BoNT/A have been challenging because of its potency...

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Detalles Bibliográficos
Autores principales:	Fernández-Salas, Ester, Wang, Joanne, Molina, Yanira, Nelson, Jeremy B., Jacky, Birgitte P. S., Aoki, K. Roger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504020/ https://www.ncbi.nlm.nih.gov/pubmed/23185348 http://dx.doi.org/10.1371/journal.pone.0049516

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