HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort

HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective female sex worker cohort (1985–2004) that Clade D (n = 54) is associated with a mor...

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Detalles Bibliográficos
Autores principales: McKinnon, Lyle R., Nagelkerke, Nico J., Kaul, Rupert, Shaw, Souradet Y., Capina, Rupert, Luo, Ma, Kariri, Anthony, Apidi, Winnie, Kimani, Makobu, Wachihi, Charles, Jaoko, Walter, Anzala, A. Omu, Kimani, Joshua, Ball, T. Blake, Plummer, Francis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504142/
https://www.ncbi.nlm.nih.gov/pubmed/23185441
http://dx.doi.org/10.1371/journal.pone.0049797
Descripción
Sumario:HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective female sex worker cohort (1985–2004) that Clade D (n = 54) is associated with a more rapid CD4 decline than clade A1 (n = 150, 20.6% vs 13.4% decline per year, 1.53-fold increase, p = 0.015). This was independent of “protective” HLA and country of origin (p = 0.053), which in turn were also independent predictors of the rate of CD4 decline (p = 0.026 and 0.005, respectively). These data confirm that clade D is more pathogenic than clade A1. The precise reason for this difference is currently unclear, and requires further study. This is first study to demonstrate difference in HIV-1 disease progression between clades while controlling for protective HLA alleles.

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