Wnt/ß-Catenin: A New Therapeutic Approach to Acute Myeloid Leukemia

Recent studies have shown genetic and epigenetic aberrations resulting in aberrant activation of the Wingless-Int (Wnt) pathway, thus influencing the initiation and progression of acute myeloid leukemia (AML). Of major importance, these findings may lead to novel treatment strategies exploiting targ...

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Detalles Bibliográficos
Autores principales: Kim, Y., Thanendrarajan, S., Schmidt-Wolf, I. G. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504236/
https://www.ncbi.nlm.nih.gov/pubmed/23213543
http://dx.doi.org/10.4061/2011/428960
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author Kim, Y.
Thanendrarajan, S.
Schmidt-Wolf, I. G. H.
author_facet Kim, Y.
Thanendrarajan, S.
Schmidt-Wolf, I. G. H.
author_sort Kim, Y.
collection PubMed
description Recent studies have shown genetic and epigenetic aberrations resulting in aberrant activation of the Wingless-Int (Wnt) pathway, thus influencing the initiation and progression of acute myeloid leukemia (AML). Of major importance, these findings may lead to novel treatment strategies exploiting targeted modulation of Wnt signaling. This paper comprises the latest status of knowledge concerning the role of Wnt pathway alteration in AML and outlines future lines of research and their clinical perspectives.
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spelling pubmed-35042362012-12-04 Wnt/ß-Catenin: A New Therapeutic Approach to Acute Myeloid Leukemia Kim, Y. Thanendrarajan, S. Schmidt-Wolf, I. G. H. Leuk Res Treatment Review Article Recent studies have shown genetic and epigenetic aberrations resulting in aberrant activation of the Wingless-Int (Wnt) pathway, thus influencing the initiation and progression of acute myeloid leukemia (AML). Of major importance, these findings may lead to novel treatment strategies exploiting targeted modulation of Wnt signaling. This paper comprises the latest status of knowledge concerning the role of Wnt pathway alteration in AML and outlines future lines of research and their clinical perspectives. SAGE-Hindawi Access to Research 2011 2011-12-01 /pmc/articles/PMC3504236/ /pubmed/23213543 http://dx.doi.org/10.4061/2011/428960 Text en Copyright © 2011 Y. Kim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Y.
Thanendrarajan, S.
Schmidt-Wolf, I. G. H.
Wnt/ß-Catenin: A New Therapeutic Approach to Acute Myeloid Leukemia
title Wnt/ß-Catenin: A New Therapeutic Approach to Acute Myeloid Leukemia
title_full Wnt/ß-Catenin: A New Therapeutic Approach to Acute Myeloid Leukemia
title_fullStr Wnt/ß-Catenin: A New Therapeutic Approach to Acute Myeloid Leukemia
title_full_unstemmed Wnt/ß-Catenin: A New Therapeutic Approach to Acute Myeloid Leukemia
title_short Wnt/ß-Catenin: A New Therapeutic Approach to Acute Myeloid Leukemia
title_sort wnt/ß-catenin: a new therapeutic approach to acute myeloid leukemia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504236/
https://www.ncbi.nlm.nih.gov/pubmed/23213543
http://dx.doi.org/10.4061/2011/428960
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