Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia

It has been revealed that the Wnt/β-catenin signaling pathway plays an important role in the development of solid tumors and hematological malignancies, particularly in B-cell neoplasia and leukemia. In the last decade there have been made experimental approaches targeting the Wnt pathway in chronic...

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Detalles Bibliográficos
Autores principales: Thanendrarajan, S., Kim, Y., Schmidt-Wolf, I. G. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504253/
https://www.ncbi.nlm.nih.gov/pubmed/23213540
http://dx.doi.org/10.4061/2011/329572
Descripción
Sumario:It has been revealed that the Wnt/β-catenin signaling pathway plays an important role in the development of solid tumors and hematological malignancies, particularly in B-cell neoplasia and leukemia. In the last decade there have been made experimental approaches targeting the Wnt pathway in chronic leukemia. In this paper we provide an overview about the current state of knowledge regarding the Wnt/β-catenin signaling pathway in chronic leukemia with special focus on therapeutic options and strategies.

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