Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia

It has been revealed that the Wnt/β-catenin signaling pathway plays an important role in the development of solid tumors and hematological malignancies, particularly in B-cell neoplasia and leukemia. In the last decade there have been made experimental approaches targeting the Wnt pathway in chronic...

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Detalles Bibliográficos
Autores principales: Thanendrarajan, S., Kim, Y., Schmidt-Wolf, I. G. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504253/
https://www.ncbi.nlm.nih.gov/pubmed/23213540
http://dx.doi.org/10.4061/2011/329572
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author Thanendrarajan, S.
Kim, Y.
Schmidt-Wolf, I. G. H.
author_facet Thanendrarajan, S.
Kim, Y.
Schmidt-Wolf, I. G. H.
author_sort Thanendrarajan, S.
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description It has been revealed that the Wnt/β-catenin signaling pathway plays an important role in the development of solid tumors and hematological malignancies, particularly in B-cell neoplasia and leukemia. In the last decade there have been made experimental approaches targeting the Wnt pathway in chronic leukemia. In this paper we provide an overview about the current state of knowledge regarding the Wnt/β-catenin signaling pathway in chronic leukemia with special focus on therapeutic options and strategies.
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spelling pubmed-35042532012-12-04 Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia Thanendrarajan, S. Kim, Y. Schmidt-Wolf, I. G. H. Leuk Res Treatment Review Article It has been revealed that the Wnt/β-catenin signaling pathway plays an important role in the development of solid tumors and hematological malignancies, particularly in B-cell neoplasia and leukemia. In the last decade there have been made experimental approaches targeting the Wnt pathway in chronic leukemia. In this paper we provide an overview about the current state of knowledge regarding the Wnt/β-catenin signaling pathway in chronic leukemia with special focus on therapeutic options and strategies. SAGE-Hindawi Access to Research 2011 2011-12-04 /pmc/articles/PMC3504253/ /pubmed/23213540 http://dx.doi.org/10.4061/2011/329572 Text en Copyright © 2011 S. Thanendrarajan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Thanendrarajan, S.
Kim, Y.
Schmidt-Wolf, I. G. H.
Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia
title Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia
title_full Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia
title_fullStr Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia
title_full_unstemmed Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia
title_short Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia
title_sort understanding and targeting the wnt/β-catenin signaling pathway in chronic leukemia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504253/
https://www.ncbi.nlm.nih.gov/pubmed/23213540
http://dx.doi.org/10.4061/2011/329572
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