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Motor Cortex Stimulation in Parkinson's Disease

Motor Cortex Stimulation (MCS) is less efficacious than Deep Brain Stimulation (DBS) in Parkinson's disease. However, it might be proposed to patients excluded from DBS or unresponsive to DBS. Ten patients with advanced PD underwent unilateral MCS contralaterally to the worst clinical side. A p...

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Autores principales: De Rose, Marisa, Guzzi, Giusy, Bosco, Domenico, Romano, Mary, Lavano, Serena Marianna, Plastino, Massimiliano, Volpentesta, Giorgio, Marotta, Rosa, Lavano, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504447/
https://www.ncbi.nlm.nih.gov/pubmed/23213520
http://dx.doi.org/10.1155/2012/502096
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author De Rose, Marisa
Guzzi, Giusy
Bosco, Domenico
Romano, Mary
Lavano, Serena Marianna
Plastino, Massimiliano
Volpentesta, Giorgio
Marotta, Rosa
Lavano, Angelo
author_facet De Rose, Marisa
Guzzi, Giusy
Bosco, Domenico
Romano, Mary
Lavano, Serena Marianna
Plastino, Massimiliano
Volpentesta, Giorgio
Marotta, Rosa
Lavano, Angelo
author_sort De Rose, Marisa
collection PubMed
description Motor Cortex Stimulation (MCS) is less efficacious than Deep Brain Stimulation (DBS) in Parkinson's disease. However, it might be proposed to patients excluded from DBS or unresponsive to DBS. Ten patients with advanced PD underwent unilateral MCS contralaterally to the worst clinical side. A plate electrode was positioned over the motor cortex in the epidural space through single burr hole after identification of the area with neuronavigation and neurophysiological tests. Clinical assessment was performed by total UPDRS, UPDRS III total, UPDRS III-items 27–31, UPDRS IV, and UPDRS II before implantation in off-medication and on-medication states and after surgery at 1, 3, 6, 12, 18, 24, and 36 months in on-medication/on-stimulation and off-medication/on-stimulation states. We assessed changes of quality of life, throughout the Parkinson's disease quality of life scale (PDQoL-39), and the dose of anti-Parkinson's disease medications, throughout the Ldopa equivalent daily dose (LEDD). During off-medication state, we observed moderate and transitory reduction of total UPDRS and UPDRS total scores and significant and long-lasting improvement in UPDRS III items 27–31 score for axial symptoms. There was marked reduction of UPDRS IV score and LEDD. PDQL-39 improvement was also significant. No important complications and adverse events occurred.
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spelling pubmed-35044472012-12-04 Motor Cortex Stimulation in Parkinson's Disease De Rose, Marisa Guzzi, Giusy Bosco, Domenico Romano, Mary Lavano, Serena Marianna Plastino, Massimiliano Volpentesta, Giorgio Marotta, Rosa Lavano, Angelo Neurol Res Int Clinical Study Motor Cortex Stimulation (MCS) is less efficacious than Deep Brain Stimulation (DBS) in Parkinson's disease. However, it might be proposed to patients excluded from DBS or unresponsive to DBS. Ten patients with advanced PD underwent unilateral MCS contralaterally to the worst clinical side. A plate electrode was positioned over the motor cortex in the epidural space through single burr hole after identification of the area with neuronavigation and neurophysiological tests. Clinical assessment was performed by total UPDRS, UPDRS III total, UPDRS III-items 27–31, UPDRS IV, and UPDRS II before implantation in off-medication and on-medication states and after surgery at 1, 3, 6, 12, 18, 24, and 36 months in on-medication/on-stimulation and off-medication/on-stimulation states. We assessed changes of quality of life, throughout the Parkinson's disease quality of life scale (PDQoL-39), and the dose of anti-Parkinson's disease medications, throughout the Ldopa equivalent daily dose (LEDD). During off-medication state, we observed moderate and transitory reduction of total UPDRS and UPDRS total scores and significant and long-lasting improvement in UPDRS III items 27–31 score for axial symptoms. There was marked reduction of UPDRS IV score and LEDD. PDQL-39 improvement was also significant. No important complications and adverse events occurred. Hindawi Publishing Corporation 2012 2012-11-08 /pmc/articles/PMC3504447/ /pubmed/23213520 http://dx.doi.org/10.1155/2012/502096 Text en Copyright © 2012 Marisa De Rose et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
De Rose, Marisa
Guzzi, Giusy
Bosco, Domenico
Romano, Mary
Lavano, Serena Marianna
Plastino, Massimiliano
Volpentesta, Giorgio
Marotta, Rosa
Lavano, Angelo
Motor Cortex Stimulation in Parkinson's Disease
title Motor Cortex Stimulation in Parkinson's Disease
title_full Motor Cortex Stimulation in Parkinson's Disease
title_fullStr Motor Cortex Stimulation in Parkinson's Disease
title_full_unstemmed Motor Cortex Stimulation in Parkinson's Disease
title_short Motor Cortex Stimulation in Parkinson's Disease
title_sort motor cortex stimulation in parkinson's disease
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504447/
https://www.ncbi.nlm.nih.gov/pubmed/23213520
http://dx.doi.org/10.1155/2012/502096
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