Cargando…
Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish
Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. Besides their electrophysiological functions in the heart, recent findings have demonstrated...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504466/ https://www.ncbi.nlm.nih.gov/pubmed/23213340 http://dx.doi.org/10.1155/2012/462161 |
_version_ | 1782250635675041792 |
---|---|
author | Keßler, Mirjam Just, Steffen Rottbauer, Wolfgang |
author_facet | Keßler, Mirjam Just, Steffen Rottbauer, Wolfgang |
author_sort | Keßler, Mirjam |
collection | PubMed |
description | Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. Besides their electrophysiological functions in the heart, recent findings have demonstrated that ion channels also feature ion flux independent functions during heart development and morphogenesis. The zebrafish is a well-established animal model to decipher the genetics of cardiovascular development and disease of vertebrates. In large scale forward genetics screens, hundreds of mutant lines have been isolated with defects in cardiovascular structure and function. Detailed phenotyping of these lines and identification of the causative genetic defects revealed new insights into ion flux dependent and independent functions of various cardiac ion channels. |
format | Online Article Text |
id | pubmed-3504466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35044662012-12-04 Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish Keßler, Mirjam Just, Steffen Rottbauer, Wolfgang Stem Cells Int Review Article Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. Besides their electrophysiological functions in the heart, recent findings have demonstrated that ion channels also feature ion flux independent functions during heart development and morphogenesis. The zebrafish is a well-established animal model to decipher the genetics of cardiovascular development and disease of vertebrates. In large scale forward genetics screens, hundreds of mutant lines have been isolated with defects in cardiovascular structure and function. Detailed phenotyping of these lines and identification of the causative genetic defects revealed new insights into ion flux dependent and independent functions of various cardiac ion channels. Hindawi Publishing Corporation 2012 2012-11-13 /pmc/articles/PMC3504466/ /pubmed/23213340 http://dx.doi.org/10.1155/2012/462161 Text en Copyright © 2012 Mirjam Keßler et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Keßler, Mirjam Just, Steffen Rottbauer, Wolfgang Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish |
title | Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish |
title_full | Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish |
title_fullStr | Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish |
title_full_unstemmed | Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish |
title_short | Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish |
title_sort | ion flux dependent and independent functions of ion channels in the vertebrate heart: lessons learned from zebrafish |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504466/ https://www.ncbi.nlm.nih.gov/pubmed/23213340 http://dx.doi.org/10.1155/2012/462161 |
work_keys_str_mv | AT keßlermirjam ionfluxdependentandindependentfunctionsofionchannelsinthevertebrateheartlessonslearnedfromzebrafish AT juststeffen ionfluxdependentandindependentfunctionsofionchannelsinthevertebrateheartlessonslearnedfromzebrafish AT rottbauerwolfgang ionfluxdependentandindependentfunctionsofionchannelsinthevertebrateheartlessonslearnedfromzebrafish |