Cargando…

Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish

Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. Besides their electrophysiological functions in the heart, recent findings have demonstrated...

Descripción completa

Detalles Bibliográficos
Autores principales: Keßler, Mirjam, Just, Steffen, Rottbauer, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504466/
https://www.ncbi.nlm.nih.gov/pubmed/23213340
http://dx.doi.org/10.1155/2012/462161
_version_ 1782250635675041792
author Keßler, Mirjam
Just, Steffen
Rottbauer, Wolfgang
author_facet Keßler, Mirjam
Just, Steffen
Rottbauer, Wolfgang
author_sort Keßler, Mirjam
collection PubMed
description Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. Besides their electrophysiological functions in the heart, recent findings have demonstrated that ion channels also feature ion flux independent functions during heart development and morphogenesis. The zebrafish is a well-established animal model to decipher the genetics of cardiovascular development and disease of vertebrates. In large scale forward genetics screens, hundreds of mutant lines have been isolated with defects in cardiovascular structure and function. Detailed phenotyping of these lines and identification of the causative genetic defects revealed new insights into ion flux dependent and independent functions of various cardiac ion channels.
format Online
Article
Text
id pubmed-3504466
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-35044662012-12-04 Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish Keßler, Mirjam Just, Steffen Rottbauer, Wolfgang Stem Cells Int Review Article Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. Besides their electrophysiological functions in the heart, recent findings have demonstrated that ion channels also feature ion flux independent functions during heart development and morphogenesis. The zebrafish is a well-established animal model to decipher the genetics of cardiovascular development and disease of vertebrates. In large scale forward genetics screens, hundreds of mutant lines have been isolated with defects in cardiovascular structure and function. Detailed phenotyping of these lines and identification of the causative genetic defects revealed new insights into ion flux dependent and independent functions of various cardiac ion channels. Hindawi Publishing Corporation 2012 2012-11-13 /pmc/articles/PMC3504466/ /pubmed/23213340 http://dx.doi.org/10.1155/2012/462161 Text en Copyright © 2012 Mirjam Keßler et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Keßler, Mirjam
Just, Steffen
Rottbauer, Wolfgang
Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish
title Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish
title_full Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish
title_fullStr Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish
title_full_unstemmed Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish
title_short Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish
title_sort ion flux dependent and independent functions of ion channels in the vertebrate heart: lessons learned from zebrafish
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504466/
https://www.ncbi.nlm.nih.gov/pubmed/23213340
http://dx.doi.org/10.1155/2012/462161
work_keys_str_mv AT keßlermirjam ionfluxdependentandindependentfunctionsofionchannelsinthevertebrateheartlessonslearnedfromzebrafish
AT juststeffen ionfluxdependentandindependentfunctionsofionchannelsinthevertebrateheartlessonslearnedfromzebrafish
AT rottbauerwolfgang ionfluxdependentandindependentfunctionsofionchannelsinthevertebrateheartlessonslearnedfromzebrafish