Cargando…

The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives

BACKGROUND: Schizophrenia is a complex psychiatric disorder characterized by high phenotypic heterogeneity. Previous studies have distinguished between familial and sporadic forms of schizophrenia and have suggested clinical differentiation between patients and relatives from sporadic and multiplex...

Descripción completa

Detalles Bibliográficos
Autores principales: Derks, Eske M, Boks, Marco PM, Vermunt, Jeroen K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504553/
https://www.ncbi.nlm.nih.gov/pubmed/22759464
http://dx.doi.org/10.1186/1471-244X-12-71
_version_ 1782250653868883968
author Derks, Eske M
Boks, Marco PM
Vermunt, Jeroen K
author_facet Derks, Eske M
Boks, Marco PM
Vermunt, Jeroen K
author_sort Derks, Eske M
collection PubMed
description BACKGROUND: Schizophrenia is a complex psychiatric disorder characterized by high phenotypic heterogeneity. Previous studies have distinguished between familial and sporadic forms of schizophrenia and have suggested clinical differentiation between patients and relatives from sporadic and multiplex families. We will introduce a more refined method to distinguish between family subtypes based on psychosis dimension profiles in the relatives of schizophrenia patients. METHODS: Positive, negative, disorganization, mania, and depression scores were assessed in 1,392 relatives. Mixed Model Latent Class Analysis was used to identify family subtypes. A family subtype is a relatively homogeneous group of families with similar symptom profiles in the relatives in these families. Next, we investigated in 616 schizophrenia patients whether family subtype was associated with symptom profiles, IQ, cannabis dependence/abuse, or age of onset of psychosis. RESULTS: Based on the data of relatives, we identified two different family types: “healthy” and “at risk for psychiatric disorder”. Patients from at risk families obtained higher positive scores compared to patients from healthy families (Wald(1) = 6.6293, p = 0.010). No significant differences were found in any of the remaining variables. CONCLUSIONS: Our findings confirm the existence of high-risk families and although we did not establish an etiological basis for the distinction between family types, genetic studies might reveal whether family subtype is associated with genetic heterogeneity.
format Online
Article
Text
id pubmed-3504553
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-35045532012-11-23 The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives Derks, Eske M Boks, Marco PM Vermunt, Jeroen K BMC Psychiatry Research Article BACKGROUND: Schizophrenia is a complex psychiatric disorder characterized by high phenotypic heterogeneity. Previous studies have distinguished between familial and sporadic forms of schizophrenia and have suggested clinical differentiation between patients and relatives from sporadic and multiplex families. We will introduce a more refined method to distinguish between family subtypes based on psychosis dimension profiles in the relatives of schizophrenia patients. METHODS: Positive, negative, disorganization, mania, and depression scores were assessed in 1,392 relatives. Mixed Model Latent Class Analysis was used to identify family subtypes. A family subtype is a relatively homogeneous group of families with similar symptom profiles in the relatives in these families. Next, we investigated in 616 schizophrenia patients whether family subtype was associated with symptom profiles, IQ, cannabis dependence/abuse, or age of onset of psychosis. RESULTS: Based on the data of relatives, we identified two different family types: “healthy” and “at risk for psychiatric disorder”. Patients from at risk families obtained higher positive scores compared to patients from healthy families (Wald(1) = 6.6293, p = 0.010). No significant differences were found in any of the remaining variables. CONCLUSIONS: Our findings confirm the existence of high-risk families and although we did not establish an etiological basis for the distinction between family types, genetic studies might reveal whether family subtype is associated with genetic heterogeneity. BioMed Central 2012-07-03 /pmc/articles/PMC3504553/ /pubmed/22759464 http://dx.doi.org/10.1186/1471-244X-12-71 Text en Copyright ©2012 Derks et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Derks, Eske M
Boks, Marco PM
Vermunt, Jeroen K
The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives
title The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives
title_full The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives
title_fullStr The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives
title_full_unstemmed The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives
title_short The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives
title_sort identification of family subtype based on the assessment of subclinical levels of psychosis in relatives
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504553/
https://www.ncbi.nlm.nih.gov/pubmed/22759464
http://dx.doi.org/10.1186/1471-244X-12-71
work_keys_str_mv AT derkseskem theidentificationoffamilysubtypebasedontheassessmentofsubclinicallevelsofpsychosisinrelatives
AT boksmarcopm theidentificationoffamilysubtypebasedontheassessmentofsubclinicallevelsofpsychosisinrelatives
AT vermuntjeroenk theidentificationoffamilysubtypebasedontheassessmentofsubclinicallevelsofpsychosisinrelatives
AT derkseskem identificationoffamilysubtypebasedontheassessmentofsubclinicallevelsofpsychosisinrelatives
AT boksmarcopm identificationoffamilysubtypebasedontheassessmentofsubclinicallevelsofpsychosisinrelatives
AT vermuntjeroenk identificationoffamilysubtypebasedontheassessmentofsubclinicallevelsofpsychosisinrelatives