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Cardiovascular determinants of prognosis in normotensive hemodialysis patients

BACKGROUND: Normotension has been hold to be the goal of hemodialysis. It remains obscure which cardiovascular parameter determines the prognosis in these normotensive hemodialysis patients. METHODS: We prospectively enrolled 145 hemodialysis patients, who had attained normotension without anti-hype...

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Autores principales: Yu, Wen-Chung, Lin, Yao-Ping, Chuang, Shao-Yuan, Lin, I-Feng, Chenb, Chen-Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504582/
https://www.ncbi.nlm.nih.gov/pubmed/22994452
http://dx.doi.org/10.1186/1471-2369-13-115
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author Yu, Wen-Chung
Lin, Yao-Ping
Chuang, Shao-Yuan
Lin, I-Feng
Chenb, Chen-Huan
author_facet Yu, Wen-Chung
Lin, Yao-Ping
Chuang, Shao-Yuan
Lin, I-Feng
Chenb, Chen-Huan
author_sort Yu, Wen-Chung
collection PubMed
description BACKGROUND: Normotension has been hold to be the goal of hemodialysis. It remains obscure which cardiovascular parameter determines the prognosis in these normotensive hemodialysis patients. METHODS: We prospectively enrolled 145 hemodialysis patients, who had attained normotension without anti-hypertensive medications, and followed them for 72.6 ± 28.5 months. Important cardiovascular parameters were obtained at enrollment. Predictors for all-cause and cardiovascular mortalities were identified with the Cox model. RESULTS: There were 45 (18 cardiovascular/27 non-cardiovascular) deaths occurred during follow-up. Age, diabetes, left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), carotid intima-media thickness (CIMT), and aortic pulse wave velocity (PWV) were significant predictors for all-cause and cardiovascular mortalities. After adjustment for age and diabetes, only LVEF was significantly associated with all-cause mortality. LVEF was significantly associated with cardiovascular mortality. LVEF remained as a significant independent predictor of cardiovascular death after adjusting for age, diabetes, LVMI, CIMT, or PWV, respectively. CONCLUSION: LVEF is the independent predictor for all-cause and cardiovascular mortalities in the normotensive hemodialysis patients.
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spelling pubmed-35045822012-11-23 Cardiovascular determinants of prognosis in normotensive hemodialysis patients Yu, Wen-Chung Lin, Yao-Ping Chuang, Shao-Yuan Lin, I-Feng Chenb, Chen-Huan BMC Nephrol Research Article BACKGROUND: Normotension has been hold to be the goal of hemodialysis. It remains obscure which cardiovascular parameter determines the prognosis in these normotensive hemodialysis patients. METHODS: We prospectively enrolled 145 hemodialysis patients, who had attained normotension without anti-hypertensive medications, and followed them for 72.6 ± 28.5 months. Important cardiovascular parameters were obtained at enrollment. Predictors for all-cause and cardiovascular mortalities were identified with the Cox model. RESULTS: There were 45 (18 cardiovascular/27 non-cardiovascular) deaths occurred during follow-up. Age, diabetes, left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), carotid intima-media thickness (CIMT), and aortic pulse wave velocity (PWV) were significant predictors for all-cause and cardiovascular mortalities. After adjustment for age and diabetes, only LVEF was significantly associated with all-cause mortality. LVEF was significantly associated with cardiovascular mortality. LVEF remained as a significant independent predictor of cardiovascular death after adjusting for age, diabetes, LVMI, CIMT, or PWV, respectively. CONCLUSION: LVEF is the independent predictor for all-cause and cardiovascular mortalities in the normotensive hemodialysis patients. BioMed Central 2012-09-20 /pmc/articles/PMC3504582/ /pubmed/22994452 http://dx.doi.org/10.1186/1471-2369-13-115 Text en Copyright ©2012 Yu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yu, Wen-Chung
Lin, Yao-Ping
Chuang, Shao-Yuan
Lin, I-Feng
Chenb, Chen-Huan
Cardiovascular determinants of prognosis in normotensive hemodialysis patients
title Cardiovascular determinants of prognosis in normotensive hemodialysis patients
title_full Cardiovascular determinants of prognosis in normotensive hemodialysis patients
title_fullStr Cardiovascular determinants of prognosis in normotensive hemodialysis patients
title_full_unstemmed Cardiovascular determinants of prognosis in normotensive hemodialysis patients
title_short Cardiovascular determinants of prognosis in normotensive hemodialysis patients
title_sort cardiovascular determinants of prognosis in normotensive hemodialysis patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504582/
https://www.ncbi.nlm.nih.gov/pubmed/22994452
http://dx.doi.org/10.1186/1471-2369-13-115
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