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Immune reconstitution inflammatory syndrome: A therapeutic paradox
A 41-year-old HIV positive woman was started on highly active antiretroviral therapy when her CD(4) count was 54/cu mm. Three weeks later, she developed erythematous to skin-colored plaques over the face. Investigations revealed a moderate eosinophilia, raised ESR, elevated 24-hour urinary calcium a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505432/ https://www.ncbi.nlm.nih.gov/pubmed/23189257 http://dx.doi.org/10.4103/2229-5178.101822 |
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author | Samson, Joan Felicita Suja, V. Samad, K. Abdul Sankar, S. Libu, G. K. |
author_facet | Samson, Joan Felicita Suja, V. Samad, K. Abdul Sankar, S. Libu, G. K. |
author_sort | Samson, Joan Felicita |
collection | PubMed |
description | A 41-year-old HIV positive woman was started on highly active antiretroviral therapy when her CD(4) count was 54/cu mm. Three weeks later, she developed erythematous to skin-colored plaques over the face. Investigations revealed a moderate eosinophilia, raised ESR, elevated 24-hour urinary calcium and hyperglobulinemia. Skin biopsy of the facial plaque revealed prominent epithelioid cell granulomas in the dermis. Reticulin stain showed reticulin fibers within the granulomas. Five months later, all the facial lesions regressed with continuation of HAART, with no specific treatment for facial plaques. Repeat CD(4) count was 104/cu mm. A diagnosis of cutaneous sarcoidosis occurring as a part of immune reconstitution inflammatory syndrome was made. Although systemic sarcoidosis has been reported, the occurrence of cutaneous sarcoidosis as part of immune reconstitution inflammatory syndrome has not been elucidated conclusively. |
format | Online Article Text |
id | pubmed-3505432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-35054322012-11-27 Immune reconstitution inflammatory syndrome: A therapeutic paradox Samson, Joan Felicita Suja, V. Samad, K. Abdul Sankar, S. Libu, G. K. Indian Dermatol Online J Case Report A 41-year-old HIV positive woman was started on highly active antiretroviral therapy when her CD(4) count was 54/cu mm. Three weeks later, she developed erythematous to skin-colored plaques over the face. Investigations revealed a moderate eosinophilia, raised ESR, elevated 24-hour urinary calcium and hyperglobulinemia. Skin biopsy of the facial plaque revealed prominent epithelioid cell granulomas in the dermis. Reticulin stain showed reticulin fibers within the granulomas. Five months later, all the facial lesions regressed with continuation of HAART, with no specific treatment for facial plaques. Repeat CD(4) count was 104/cu mm. A diagnosis of cutaneous sarcoidosis occurring as a part of immune reconstitution inflammatory syndrome was made. Although systemic sarcoidosis has been reported, the occurrence of cutaneous sarcoidosis as part of immune reconstitution inflammatory syndrome has not been elucidated conclusively. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3505432/ /pubmed/23189257 http://dx.doi.org/10.4103/2229-5178.101822 Text en Copyright: © Indian Dermatology Online Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Samson, Joan Felicita Suja, V. Samad, K. Abdul Sankar, S. Libu, G. K. Immune reconstitution inflammatory syndrome: A therapeutic paradox |
title | Immune reconstitution inflammatory syndrome: A therapeutic paradox |
title_full | Immune reconstitution inflammatory syndrome: A therapeutic paradox |
title_fullStr | Immune reconstitution inflammatory syndrome: A therapeutic paradox |
title_full_unstemmed | Immune reconstitution inflammatory syndrome: A therapeutic paradox |
title_short | Immune reconstitution inflammatory syndrome: A therapeutic paradox |
title_sort | immune reconstitution inflammatory syndrome: a therapeutic paradox |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505432/ https://www.ncbi.nlm.nih.gov/pubmed/23189257 http://dx.doi.org/10.4103/2229-5178.101822 |
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