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Incidence and 30-day case fatality for acute myocardial infarction in England in 2010: national-linked database study

Background: There are limited national population-based epidemiological data on acute myocardial infarction (AMI) in England, making the current burden of disease, and clinical prognosis, difficult to quantify. The aim of this study was to provide national estimates of incidence and 30-day case fata...

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Autores principales: Smolina, Kate, Wright, Frances L., Rayner, Mike, Goldacre, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505446/
https://www.ncbi.nlm.nih.gov/pubmed/22241758
http://dx.doi.org/10.1093/eurpub/ckr196
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author Smolina, Kate
Wright, Frances L.
Rayner, Mike
Goldacre, Michael J.
author_facet Smolina, Kate
Wright, Frances L.
Rayner, Mike
Goldacre, Michael J.
author_sort Smolina, Kate
collection PubMed
description Background: There are limited national population-based epidemiological data on acute myocardial infarction (AMI) in England, making the current burden of disease, and clinical prognosis, difficult to quantify. The aim of this study was to provide national estimates of incidence and 30-day case fatality rate (CFR) for first and recurrent AMI in England. Methods: Population-based study using person-linked routine hospital and mortality data on 79 896 individuals of any age, who were admitted to hospital for AMI or who died suddenly from AMI in 2010. Results: Of 82 252 AMI events in 2010, 83% were first. Age-standardized incidence of first AMI per 100 000 population was 130 (95% CI 129–131) in men and 55.9 (95% CI 55.3–56.6) in women. Age-standardized 30-day overall CFRs including sudden AMI deaths for men and women, respectively, were 32.4% (95% CI 32.0–32.9) and 30.3% (95% CI 29.8–30.9) for first AMI and 29.7% (95% CI 28.7–30.7) and 26.7% (95% CI 25.5–27.9) for recurrent AMI. Age-standardized hospitalized 30-day CFR was 12.0% (95% CI 11.6–12.3) for men and 12.3% (95% CI 11.9–12.7) for women. Conclusions: While the majority of AMIs are not fatal, of those that are, two-thirds occur as sudden AMI deaths. About one in six of all AMIs are recurrent events. These findings reinforce the importance of primary and secondary prevention in reducing AMI morbidity and mortality.
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spelling pubmed-35054462012-11-26 Incidence and 30-day case fatality for acute myocardial infarction in England in 2010: national-linked database study Smolina, Kate Wright, Frances L. Rayner, Mike Goldacre, Michael J. Eur J Public Health Cardiovascular Diseases Background: There are limited national population-based epidemiological data on acute myocardial infarction (AMI) in England, making the current burden of disease, and clinical prognosis, difficult to quantify. The aim of this study was to provide national estimates of incidence and 30-day case fatality rate (CFR) for first and recurrent AMI in England. Methods: Population-based study using person-linked routine hospital and mortality data on 79 896 individuals of any age, who were admitted to hospital for AMI or who died suddenly from AMI in 2010. Results: Of 82 252 AMI events in 2010, 83% were first. Age-standardized incidence of first AMI per 100 000 population was 130 (95% CI 129–131) in men and 55.9 (95% CI 55.3–56.6) in women. Age-standardized 30-day overall CFRs including sudden AMI deaths for men and women, respectively, were 32.4% (95% CI 32.0–32.9) and 30.3% (95% CI 29.8–30.9) for first AMI and 29.7% (95% CI 28.7–30.7) and 26.7% (95% CI 25.5–27.9) for recurrent AMI. Age-standardized hospitalized 30-day CFR was 12.0% (95% CI 11.6–12.3) for men and 12.3% (95% CI 11.9–12.7) for women. Conclusions: While the majority of AMIs are not fatal, of those that are, two-thirds occur as sudden AMI deaths. About one in six of all AMIs are recurrent events. These findings reinforce the importance of primary and secondary prevention in reducing AMI morbidity and mortality. Oxford University Press 2012-12 2012-01-11 /pmc/articles/PMC3505446/ /pubmed/22241758 http://dx.doi.org/10.1093/eurpub/ckr196 Text en © The Author 2012. Published by Oxford University Press on behalf of the European Public Health Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cardiovascular Diseases
Smolina, Kate
Wright, Frances L.
Rayner, Mike
Goldacre, Michael J.
Incidence and 30-day case fatality for acute myocardial infarction in England in 2010: national-linked database study
title Incidence and 30-day case fatality for acute myocardial infarction in England in 2010: national-linked database study
title_full Incidence and 30-day case fatality for acute myocardial infarction in England in 2010: national-linked database study
title_fullStr Incidence and 30-day case fatality for acute myocardial infarction in England in 2010: national-linked database study
title_full_unstemmed Incidence and 30-day case fatality for acute myocardial infarction in England in 2010: national-linked database study
title_short Incidence and 30-day case fatality for acute myocardial infarction in England in 2010: national-linked database study
title_sort incidence and 30-day case fatality for acute myocardial infarction in england in 2010: national-linked database study
topic Cardiovascular Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505446/
https://www.ncbi.nlm.nih.gov/pubmed/22241758
http://dx.doi.org/10.1093/eurpub/ckr196
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