Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative

We present clinical practice recommendations for the treatment of children with Alport syndrome who are not enrolled in clinical trials. Our goal is to promote early initiation of a standard therapeutic approach that will facilitate assessment of the safety and efficacy of the protocol. The treatmen...

Descripción completa

Detalles Bibliográficos
Autores principales: Kashtan, Clifford E., Ding, Jie, Gregory, Martin, Gross, Oliver, Heidet, Laurence, Knebelmann, Bertrand, Rheault, Michelle, Licht, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505543/
https://www.ncbi.nlm.nih.gov/pubmed/22461141
http://dx.doi.org/10.1007/s00467-012-2138-4
Descripción
Sumario:We present clinical practice recommendations for the treatment of children with Alport syndrome who are not enrolled in clinical trials. Our goal is to promote early initiation of a standard therapeutic approach that will facilitate assessment of the safety and efficacy of the protocol. The treatment protocol is based on the reduction of proteinuria, intraglomerular pressure, and renal fibrosis via interference with the renin–angiotensin–aldosterone system.

Ejemplares similares