Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative

We present clinical practice recommendations for the treatment of children with Alport syndrome who are not enrolled in clinical trials. Our goal is to promote early initiation of a standard therapeutic approach that will facilitate assessment of the safety and efficacy of the protocol. The treatmen...

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Detalles Bibliográficos
Autores principales: Kashtan, Clifford E., Ding, Jie, Gregory, Martin, Gross, Oliver, Heidet, Laurence, Knebelmann, Bertrand, Rheault, Michelle, Licht, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505543/
https://www.ncbi.nlm.nih.gov/pubmed/22461141
http://dx.doi.org/10.1007/s00467-012-2138-4
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author Kashtan, Clifford E.
Ding, Jie
Gregory, Martin
Gross, Oliver
Heidet, Laurence
Knebelmann, Bertrand
Rheault, Michelle
Licht, Christoph
author_facet Kashtan, Clifford E.
Ding, Jie
Gregory, Martin
Gross, Oliver
Heidet, Laurence
Knebelmann, Bertrand
Rheault, Michelle
Licht, Christoph
author_sort Kashtan, Clifford E.
collection PubMed
description We present clinical practice recommendations for the treatment of children with Alport syndrome who are not enrolled in clinical trials. Our goal is to promote early initiation of a standard therapeutic approach that will facilitate assessment of the safety and efficacy of the protocol. The treatment protocol is based on the reduction of proteinuria, intraglomerular pressure, and renal fibrosis via interference with the renin–angiotensin–aldosterone system.
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spelling pubmed-35055432012-11-28 Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative Kashtan, Clifford E. Ding, Jie Gregory, Martin Gross, Oliver Heidet, Laurence Knebelmann, Bertrand Rheault, Michelle Licht, Christoph Pediatr Nephrol Review We present clinical practice recommendations for the treatment of children with Alport syndrome who are not enrolled in clinical trials. Our goal is to promote early initiation of a standard therapeutic approach that will facilitate assessment of the safety and efficacy of the protocol. The treatment protocol is based on the reduction of proteinuria, intraglomerular pressure, and renal fibrosis via interference with the renin–angiotensin–aldosterone system. Springer-Verlag 2012-03-30 2013 /pmc/articles/PMC3505543/ /pubmed/22461141 http://dx.doi.org/10.1007/s00467-012-2138-4 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Kashtan, Clifford E.
Ding, Jie
Gregory, Martin
Gross, Oliver
Heidet, Laurence
Knebelmann, Bertrand
Rheault, Michelle
Licht, Christoph
Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative
title Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative
title_full Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative
title_fullStr Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative
title_full_unstemmed Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative
title_short Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative
title_sort clinical practice recommendations for the treatment of alport syndrome: a statement of the alport syndrome research collaborative
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505543/
https://www.ncbi.nlm.nih.gov/pubmed/22461141
http://dx.doi.org/10.1007/s00467-012-2138-4
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