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Serum Adiponectin Level and Different Kinds of Cancer: A Review of Recent Evidence

Background. Adiponectin, an adipokine secreted from adipose tissue, has antiobesity, anti-insulin resistance, and anticancer roles. The present study aimed to review the epidemiologic evidence about the association between adiponectin and cancers. Method. We searched in PubMed from 2002 to October 2...

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Detalles Bibliográficos
Autores principales: Izadi, Vajihe, Farabad, Elaheh, Azadbakht, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505647/
https://www.ncbi.nlm.nih.gov/pubmed/23213569
http://dx.doi.org/10.5402/2012/982769
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author Izadi, Vajihe
Farabad, Elaheh
Azadbakht, Leila
author_facet Izadi, Vajihe
Farabad, Elaheh
Azadbakht, Leila
author_sort Izadi, Vajihe
collection PubMed
description Background. Adiponectin, an adipokine secreted from adipose tissue, has antiobesity, anti-insulin resistance, and anticancer roles. The present study aimed to review the epidemiologic evidence about the association between adiponectin and cancers. Method. We searched in PubMed from 2002 to October 2011 by using the following key words: cancer, malignancy, cell proliferation, and adiponectin. Finally, 45 articles were recruited to review in the present paper. Findings. Several findings suggested inverse association between concentration of hormone and breast cancer risk. Low levels of adiponectin increase the risk of endometrial cancer in women. Adiponectin levels were significantly associated with prostate cancer in men. It seems that there is an inverse relationship between levels of adiponectin or its gene and colorectal cancer. Significant association between hormone and pancreatic cancer was found. Conclusion. Several findings suggested the negative correlation between adiponectin and risk of cancers. This relationship was more elucidated by the correlation between the hormone with obesity and insulin resistance. Suppression of growth and proliferation of cancer cells by adiponectin were explained via several mechanisms.
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spelling pubmed-35056472012-12-04 Serum Adiponectin Level and Different Kinds of Cancer: A Review of Recent Evidence Izadi, Vajihe Farabad, Elaheh Azadbakht, Leila ISRN Oncol Review Article Background. Adiponectin, an adipokine secreted from adipose tissue, has antiobesity, anti-insulin resistance, and anticancer roles. The present study aimed to review the epidemiologic evidence about the association between adiponectin and cancers. Method. We searched in PubMed from 2002 to October 2011 by using the following key words: cancer, malignancy, cell proliferation, and adiponectin. Finally, 45 articles were recruited to review in the present paper. Findings. Several findings suggested inverse association between concentration of hormone and breast cancer risk. Low levels of adiponectin increase the risk of endometrial cancer in women. Adiponectin levels were significantly associated with prostate cancer in men. It seems that there is an inverse relationship between levels of adiponectin or its gene and colorectal cancer. Significant association between hormone and pancreatic cancer was found. Conclusion. Several findings suggested the negative correlation between adiponectin and risk of cancers. This relationship was more elucidated by the correlation between the hormone with obesity and insulin resistance. Suppression of growth and proliferation of cancer cells by adiponectin were explained via several mechanisms. International Scholarly Research Network 2012-11-18 /pmc/articles/PMC3505647/ /pubmed/23213569 http://dx.doi.org/10.5402/2012/982769 Text en Copyright © 2012 Vajihe Izadi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Izadi, Vajihe
Farabad, Elaheh
Azadbakht, Leila
Serum Adiponectin Level and Different Kinds of Cancer: A Review of Recent Evidence
title Serum Adiponectin Level and Different Kinds of Cancer: A Review of Recent Evidence
title_full Serum Adiponectin Level and Different Kinds of Cancer: A Review of Recent Evidence
title_fullStr Serum Adiponectin Level and Different Kinds of Cancer: A Review of Recent Evidence
title_full_unstemmed Serum Adiponectin Level and Different Kinds of Cancer: A Review of Recent Evidence
title_short Serum Adiponectin Level and Different Kinds of Cancer: A Review of Recent Evidence
title_sort serum adiponectin level and different kinds of cancer: a review of recent evidence
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505647/
https://www.ncbi.nlm.nih.gov/pubmed/23213569
http://dx.doi.org/10.5402/2012/982769
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