Cargando…
Mesenchymal dental stem cells in regenerative dentistry
In the last decade, tissue engineering is a field that has been suffering an enormous expansion in the regenerative medicine and dentistry. The use of cells as mesenchymal dental stem cells of easy access for dentist and oral surgeon, immunosuppressive properties, high proliferation and capacity to...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medicina Oral S.L.
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505703/ https://www.ncbi.nlm.nih.gov/pubmed/22926467 http://dx.doi.org/10.4317/medoral.17925 |
_version_ | 1782250794812178432 |
---|---|
author | Rodríguez-Lozano, Francisco-Javier Insausti, Carmen-Luisa Iniesta, Francisca Blanquer, Miguel Ramírez, María-del-Carmen Meseguer, Luis Meseguer-Henarejos, Ana-Belén Marín, Noemí Martínez, Salvador Moraleda, José-María |
author_facet | Rodríguez-Lozano, Francisco-Javier Insausti, Carmen-Luisa Iniesta, Francisca Blanquer, Miguel Ramírez, María-del-Carmen Meseguer, Luis Meseguer-Henarejos, Ana-Belén Marín, Noemí Martínez, Salvador Moraleda, José-María |
author_sort | Rodríguez-Lozano, Francisco-Javier |
collection | PubMed |
description | In the last decade, tissue engineering is a field that has been suffering an enormous expansion in the regenerative medicine and dentistry. The use of cells as mesenchymal dental stem cells of easy access for dentist and oral surgeon, immunosuppressive properties, high proliferation and capacity to differentiate into odontoblasts, cementoblasts, osteoblasts and other cells implicated in the teeth, suppose a good perspective of future in the clinical dentistry. However, is necessary advance in the known of growth factors and signalling molecules implicated in tooth development and regeneration of different structures of teeth. Furthermore, these cells need a fabulous scaffold that facility their integration, differentiation, matrix synthesis and promote multiple specific interactions between cells. In this review, we give a brief description of tooth development and anatomy, definition and classification of stem cells, with special attention of mesenchymal stem cells, commonly used in the cellular therapy for their trasdifferentiation ability, non ethical problems and acceptable results in preliminary clinical trials. In terms of tissue engineering, we provide an overview of different types of mesenchymal stem cells that have been isolated from teeth, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHEDs), periodontal ligament stem cells (PDLSCs), dental follicle progenitor stem cells (DFPCs), and stem cells from apical papilla (SCAPs), growth factors implicated in regeneration teeth and types of scaffolds for dental tissue regeneration. Key words:Dental stem cells, regenerative dentistry, mesenchymal stem cells, tissue engineering, stem cells. |
format | Online Article Text |
id | pubmed-3505703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medicina Oral S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35057032012-12-03 Mesenchymal dental stem cells in regenerative dentistry Rodríguez-Lozano, Francisco-Javier Insausti, Carmen-Luisa Iniesta, Francisca Blanquer, Miguel Ramírez, María-del-Carmen Meseguer, Luis Meseguer-Henarejos, Ana-Belén Marín, Noemí Martínez, Salvador Moraleda, José-María Med Oral Patol Oral Cir Bucal Review-Article In the last decade, tissue engineering is a field that has been suffering an enormous expansion in the regenerative medicine and dentistry. The use of cells as mesenchymal dental stem cells of easy access for dentist and oral surgeon, immunosuppressive properties, high proliferation and capacity to differentiate into odontoblasts, cementoblasts, osteoblasts and other cells implicated in the teeth, suppose a good perspective of future in the clinical dentistry. However, is necessary advance in the known of growth factors and signalling molecules implicated in tooth development and regeneration of different structures of teeth. Furthermore, these cells need a fabulous scaffold that facility their integration, differentiation, matrix synthesis and promote multiple specific interactions between cells. In this review, we give a brief description of tooth development and anatomy, definition and classification of stem cells, with special attention of mesenchymal stem cells, commonly used in the cellular therapy for their trasdifferentiation ability, non ethical problems and acceptable results in preliminary clinical trials. In terms of tissue engineering, we provide an overview of different types of mesenchymal stem cells that have been isolated from teeth, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHEDs), periodontal ligament stem cells (PDLSCs), dental follicle progenitor stem cells (DFPCs), and stem cells from apical papilla (SCAPs), growth factors implicated in regeneration teeth and types of scaffolds for dental tissue regeneration. Key words:Dental stem cells, regenerative dentistry, mesenchymal stem cells, tissue engineering, stem cells. Medicina Oral S.L. 2012-11 2012-08-28 /pmc/articles/PMC3505703/ /pubmed/22926467 http://dx.doi.org/10.4317/medoral.17925 Text en Copyright: © 2012 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review-Article Rodríguez-Lozano, Francisco-Javier Insausti, Carmen-Luisa Iniesta, Francisca Blanquer, Miguel Ramírez, María-del-Carmen Meseguer, Luis Meseguer-Henarejos, Ana-Belén Marín, Noemí Martínez, Salvador Moraleda, José-María Mesenchymal dental stem cells in regenerative dentistry |
title | Mesenchymal dental stem cells in regenerative dentistry |
title_full | Mesenchymal dental stem cells in regenerative dentistry |
title_fullStr | Mesenchymal dental stem cells in regenerative dentistry |
title_full_unstemmed | Mesenchymal dental stem cells in regenerative dentistry |
title_short | Mesenchymal dental stem cells in regenerative dentistry |
title_sort | mesenchymal dental stem cells in regenerative dentistry |
topic | Review-Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505703/ https://www.ncbi.nlm.nih.gov/pubmed/22926467 http://dx.doi.org/10.4317/medoral.17925 |
work_keys_str_mv | AT rodriguezlozanofranciscojavier mesenchymaldentalstemcellsinregenerativedentistry AT insausticarmenluisa mesenchymaldentalstemcellsinregenerativedentistry AT iniestafrancisca mesenchymaldentalstemcellsinregenerativedentistry AT blanquermiguel mesenchymaldentalstemcellsinregenerativedentistry AT ramirezmariadelcarmen mesenchymaldentalstemcellsinregenerativedentistry AT meseguerluis mesenchymaldentalstemcellsinregenerativedentistry AT meseguerhenarejosanabelen mesenchymaldentalstemcellsinregenerativedentistry AT marinnoemi mesenchymaldentalstemcellsinregenerativedentistry AT martinezsalvador mesenchymaldentalstemcellsinregenerativedentistry AT moraledajosemaria mesenchymaldentalstemcellsinregenerativedentistry |